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Anti-NDUS8/ NDUFS8/ CI-23k functional antibody
Anti-NDUS8/ NDUFS8/ CI-23k functional antibody for cell culture, ELISA & in-vivo assay
Go to NDUFS8/NDUFS8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1460-Ab-1/ GM-Tg-hg-SE1460-Ab-2 | Anti-Human NDUFS8 monoclonal antibody | Human |
| GM-Tg-rg-SE1460-Ab-1/ GM-Tg-rg-SE1460-Ab-2 | Anti-Rat NDUFS8 monoclonal antibody | Rat |
| GM-Tg-mg-SE1460-Ab-1/ GM-Tg-mg-SE1460-Ab-2 | Anti-Mouse NDUFS8 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1460-Ab-1/ GM-Tg-cynog-SE1460-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NDUFS8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1460-Ab-1/ GM-Tg-felg-SE1460-Ab-2 | Anti-Feline NDUFS8 monoclonal antibody | Feline |
| GM-Tg-cang-SE1460-Ab-1/ GM-Tg-cang-SE1460-Ab-2 | Anti-Canine NDUFS8 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1460-Ab-1/ GM-Tg-bovg-SE1460-Ab-2 | Anti-Bovine NDUFS8 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1460-Ab-1/ GM-Tg-equg-SE1460-Ab-2 | Anti-Equine NDUFS8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1460-Ab-1/ GM-Tg-hg-SE1460-Ab-2; GM-Tg-rg-SE1460-Ab-1/ GM-Tg-rg-SE1460-Ab-2; GM-Tg-mg-SE1460-Ab-1/ GM-Tg-mg-SE1460-Ab-2; GM-Tg-cynog-SE1460-Ab-1/ GM-Tg-cynog-SE1460-Ab-2; GM-Tg-felg-SE1460-Ab-1/ GM-Tg-felg-SE1460-Ab-2; GM-Tg-cang-SE1460-Ab-1/ GM-Tg-cang-SE1460-Ab-2; GM-Tg-bovg-SE1460-Ab-1/ GM-Tg-bovg-SE1460-Ab-2; GM-Tg-equg-SE1460-Ab-1/ GM-Tg-equg-SE1460-Ab-2 |
| Products Name | Anti-NDUFS8 monoclonal antibody |
| Format | mab |
| Target Name | NDUFS8 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NDUFS8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1460-Ag-1 | Recombinant multi-species NDUS8/ NDUFS8/ CI-23k protein |
Target information
| Target ID | GM-SE1460 |
| Target Name | NDUFS8 |
| Gene ID | 4728,225887,293652,710845,610413,101094451,287027,100053392 |
| Gene Symbol and Synonyms | CI-23k,CI-23kD,CI23KD,MC1DN2,NDUFS8,TYKY |
| Uniprot Accession | O00217,P42028 |
| Uniprot Entry Name | NDUS8_HUMAN,NDUS8_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000110717 |
| Target Classification | N/A |
The target: NDUFS8, gene name: NDUFS8, also named as CI-23k, CI23KD, TYKY. This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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