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Anti-SYHM/ HARS2/ HARSL functional antibody
Anti-SYHM/ HARS2/ HARSL functional antibody for cell culture, ELISA & in-vivo assay
Go to HARS2/HARS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1463-Ab-1/ GM-Tg-hg-SE1463-Ab-2 | Anti-Human HARS2 monoclonal antibody | Human |
| GM-Tg-rg-SE1463-Ab-1/ GM-Tg-rg-SE1463-Ab-2 | Anti-Rat HARS2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1463-Ab-1/ GM-Tg-mg-SE1463-Ab-2 | Anti-Mouse HARS2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1463-Ab-1/ GM-Tg-cynog-SE1463-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HARS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1463-Ab-1/ GM-Tg-felg-SE1463-Ab-2 | Anti-Feline HARS2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1463-Ab-1/ GM-Tg-cang-SE1463-Ab-2 | Anti-Canine HARS2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1463-Ab-1/ GM-Tg-bovg-SE1463-Ab-2 | Anti-Bovine HARS2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1463-Ab-1/ GM-Tg-equg-SE1463-Ab-2 | Anti-Equine HARS2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1463-Ab-1/ GM-Tg-hg-SE1463-Ab-2; GM-Tg-rg-SE1463-Ab-1/ GM-Tg-rg-SE1463-Ab-2; GM-Tg-mg-SE1463-Ab-1/ GM-Tg-mg-SE1463-Ab-2; GM-Tg-cynog-SE1463-Ab-1/ GM-Tg-cynog-SE1463-Ab-2; GM-Tg-felg-SE1463-Ab-1/ GM-Tg-felg-SE1463-Ab-2; GM-Tg-cang-SE1463-Ab-1/ GM-Tg-cang-SE1463-Ab-2; GM-Tg-bovg-SE1463-Ab-1/ GM-Tg-bovg-SE1463-Ab-2; GM-Tg-equg-SE1463-Ab-1/ GM-Tg-equg-SE1463-Ab-2 |
| Products Name | Anti-HARS2 monoclonal antibody |
| Format | mab |
| Target Name | HARS2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HARS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1463-Ag-1 | Recombinant multi-species SYHM/ HARS2/ HARSL protein |
| ORF Viral Vector | vGMLP004306 | human HARS2 Lentivirus particle |
| ORF Viral Vector | pGMLP004306 | human HARS2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003359 | mouse Hars2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003359 | mouse Hars2 Lentivirus particle |
Target information
| Target ID | GM-SE1463 |
| Target Name | HARS2 |
| Gene ID | 23438,70791,307491,697009,615182,100072383 |
| Gene Symbol and Synonyms | 4631412B19Rik,HARS2,Hars2l,HARSL,HARSR,HisRS,HO3,PRLTS2,RGD1308426,Zmat2 |
| Uniprot Accession | P49590,A5D7V9 |
| Uniprot Entry Name | SYHM_HUMAN,SYHM_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000112855 |
| Target Classification | N/A |
The target: HARS2, gene name: HARS2, also named as HARSL, HARSR, HO3, HisRS, PRLTS2. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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