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Anti-NECA3/ NECAB3/ APBA2BP functional antibody
Anti-NECA3/ NECAB3/ APBA2BP functional antibody for cell culture, ELISA & in-vivo assay
Go to NECAB3/NECAB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1485-Ab-1/ GM-Tg-hg-SE1485-Ab-2 | Anti-Human NECAB3 monoclonal antibody | Human |
| GM-Tg-rg-SE1485-Ab-1/ GM-Tg-rg-SE1485-Ab-2 | Anti-Rat NECAB3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1485-Ab-1/ GM-Tg-mg-SE1485-Ab-2 | Anti-Mouse NECAB3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1485-Ab-1/ GM-Tg-cynog-SE1485-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NECAB3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1485-Ab-1/ GM-Tg-felg-SE1485-Ab-2 | Anti-Feline NECAB3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1485-Ab-1/ GM-Tg-cang-SE1485-Ab-2 | Anti-Canine NECAB3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1485-Ab-1/ GM-Tg-bovg-SE1485-Ab-2 | Anti-Bovine NECAB3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1485-Ab-1/ GM-Tg-equg-SE1485-Ab-2 | Anti-Equine NECAB3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1485-Ab-1/ GM-Tg-hg-SE1485-Ab-2; GM-Tg-rg-SE1485-Ab-1/ GM-Tg-rg-SE1485-Ab-2; GM-Tg-mg-SE1485-Ab-1/ GM-Tg-mg-SE1485-Ab-2; GM-Tg-cynog-SE1485-Ab-1/ GM-Tg-cynog-SE1485-Ab-2; GM-Tg-felg-SE1485-Ab-1/ GM-Tg-felg-SE1485-Ab-2; GM-Tg-cang-SE1485-Ab-1/ GM-Tg-cang-SE1485-Ab-2; GM-Tg-bovg-SE1485-Ab-1/ GM-Tg-bovg-SE1485-Ab-2; GM-Tg-equg-SE1485-Ab-1/ GM-Tg-equg-SE1485-Ab-2 |
| Products Name | Anti-NECAB3 monoclonal antibody |
| Format | mab |
| Target Name | NECAB3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NECAB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1485-Ag-1 | Recombinant multi-species NECA3/ NECAB3/ APBA2BP protein |
Target information
| Target ID | GM-SE1485 |
| Target Name | NECAB3 |
| Gene ID | 63941,56846,311562,100427126,608658,101098703,514695,100069158 |
| Gene Symbol and Synonyms | 2900010M17Rik,APBA2BP,dJ63M2.4,dJ63M2.5,EFCBP3,NECAB3,NIP1,STIP3,SYTIP2,XB51 |
| Uniprot Accession | Q96P71,A2VDW6 |
| Uniprot Entry Name | NECA3_HUMAN,NECA3_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000125967 |
| Target Classification | N/A |
The target: NECAB3, gene name: NECAB3, also named as APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5. The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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