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Anti-SNAT/ AANAT/ DSPS functional antibody
Anti-SNAT/ AANAT/ DSPS functional antibody for cell culture, ELISA & in-vivo assay
Go to AANAT/AANAT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1491-Ab-1/ GM-Tg-hg-SE1491-Ab-2 | Anti-Human AANAT monoclonal antibody | Human |
| GM-Tg-rg-SE1491-Ab-1/ GM-Tg-rg-SE1491-Ab-2 | Anti-Rat AANAT monoclonal antibody | Rat |
| GM-Tg-mg-SE1491-Ab-1/ GM-Tg-mg-SE1491-Ab-2 | Anti-Mouse AANAT monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1491-Ab-1/ GM-Tg-cynog-SE1491-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AANAT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1491-Ab-1/ GM-Tg-felg-SE1491-Ab-2 | Anti-Feline AANAT monoclonal antibody | Feline |
| GM-Tg-cang-SE1491-Ab-1/ GM-Tg-cang-SE1491-Ab-2 | Anti-Canine AANAT monoclonal antibody | Canine |
| GM-Tg-bovg-SE1491-Ab-1/ GM-Tg-bovg-SE1491-Ab-2 | Anti-Bovine AANAT monoclonal antibody | Bovine |
| GM-Tg-equg-SE1491-Ab-1/ GM-Tg-equg-SE1491-Ab-2 | Anti-Equine AANAT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1491-Ab-1/ GM-Tg-hg-SE1491-Ab-2; GM-Tg-rg-SE1491-Ab-1/ GM-Tg-rg-SE1491-Ab-2; GM-Tg-mg-SE1491-Ab-1/ GM-Tg-mg-SE1491-Ab-2; GM-Tg-cynog-SE1491-Ab-1/ GM-Tg-cynog-SE1491-Ab-2; GM-Tg-felg-SE1491-Ab-1/ GM-Tg-felg-SE1491-Ab-2; GM-Tg-cang-SE1491-Ab-1/ GM-Tg-cang-SE1491-Ab-2; GM-Tg-bovg-SE1491-Ab-1/ GM-Tg-bovg-SE1491-Ab-2; GM-Tg-equg-SE1491-Ab-1/ GM-Tg-equg-SE1491-Ab-2 |
| Products Name | Anti-AANAT monoclonal antibody |
| Format | mab |
| Target Name | AANAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AANAT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1491-Ag-1 | Recombinant multi-species SNAT/ AANAT/ DSPS protein |
Target information
| Target ID | GM-SE1491 |
| Target Name | AANAT |
| Gene ID | 15,11298,25120,706924,483331,101098178,112442710,100058770 |
| Gene Symbol and Synonyms | AA-NAT,AANAT,DSPS,Nat-2,Nat4,SNAT |
| Uniprot Accession | Q16613,Q64666,O97756 |
| Uniprot Entry Name | SNAT_HUMAN,SNAT_MACMU,SNAT_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000129673 |
| Target Classification | N/A |
The target: AANAT, gene name: AANAT, also named as DSPS, SNAT. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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