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Anti-PRD12/ PRDM12/ HSAN8 functional antibody
Anti-PRD12/ PRDM12/ HSAN8 functional antibody for cell culture, ELISA & in-vivo assay
Go to PRDM12/PRDM12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1494-Ab-1/ GM-Tg-hg-SE1494-Ab-2 | Anti-Human PRDM12 monoclonal antibody | Human |
| GM-Tg-rg-SE1494-Ab-1/ GM-Tg-rg-SE1494-Ab-2 | Anti-Rat PRDM12 monoclonal antibody | Rat |
| GM-Tg-mg-SE1494-Ab-1/ GM-Tg-mg-SE1494-Ab-2 | Anti-Mouse PRDM12 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1494-Ab-1/ GM-Tg-cynog-SE1494-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRDM12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1494-Ab-1/ GM-Tg-felg-SE1494-Ab-2 | Anti-Feline PRDM12 monoclonal antibody | Feline |
| GM-Tg-cang-SE1494-Ab-1/ GM-Tg-cang-SE1494-Ab-2 | Anti-Canine PRDM12 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1494-Ab-1/ GM-Tg-bovg-SE1494-Ab-2 | Anti-Bovine PRDM12 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1494-Ab-1/ GM-Tg-equg-SE1494-Ab-2 | Anti-Equine PRDM12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1494-Ab-1/ GM-Tg-hg-SE1494-Ab-2; GM-Tg-rg-SE1494-Ab-1/ GM-Tg-rg-SE1494-Ab-2; GM-Tg-mg-SE1494-Ab-1/ GM-Tg-mg-SE1494-Ab-2; GM-Tg-cynog-SE1494-Ab-1/ GM-Tg-cynog-SE1494-Ab-2; GM-Tg-felg-SE1494-Ab-1/ GM-Tg-felg-SE1494-Ab-2; GM-Tg-cang-SE1494-Ab-1/ GM-Tg-cang-SE1494-Ab-2; GM-Tg-bovg-SE1494-Ab-1/ GM-Tg-bovg-SE1494-Ab-2; GM-Tg-equg-SE1494-Ab-1/ GM-Tg-equg-SE1494-Ab-2 |
| Products Name | Anti-PRDM12 monoclonal antibody |
| Format | mab |
| Target Name | PRDM12 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PRDM12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1494-Ag-1 | Recombinant multi-species PRD12/ PRDM12/ HSAN8 protein |
Target information
| Target ID | GM-SE1494 |
| Target Name | PRDM12 |
| Gene ID | 59335,381359,688699,716040,119873358,111557554,618320,100146306 |
| Gene Symbol and Synonyms | Gm998,HSAN8,PFM9,PRDM12 |
| Uniprot Accession | Q9H4Q4 |
| Uniprot Entry Name | PRD12_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000130711 |
| Target Classification | N/A |
The target: PRDM12, gene name: PRDM12, also named as HSAN8, PFM9. This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. [provided by RefSeq, Mar 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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