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Anti-FOLC/ FPGS functional antibody
Anti-FOLC/ FPGS functional antibody for cell culture, ELISA & in-vivo assay
Go to FPGS/FPGS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1505-Ab-1/ GM-Tg-hg-SE1505-Ab-2 | Anti-Human FPGS monoclonal antibody | Human |
| GM-Tg-rg-SE1505-Ab-1/ GM-Tg-rg-SE1505-Ab-2 | Anti-Rat FPGS monoclonal antibody | Rat |
| GM-Tg-mg-SE1505-Ab-1/ GM-Tg-mg-SE1505-Ab-2 | Anti-Mouse FPGS monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1505-Ab-1/ GM-Tg-cynog-SE1505-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FPGS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1505-Ab-1/ GM-Tg-felg-SE1505-Ab-2 | Anti-Feline FPGS monoclonal antibody | Feline |
| GM-Tg-cang-SE1505-Ab-1/ GM-Tg-cang-SE1505-Ab-2 | Anti-Canine FPGS monoclonal antibody | Canine |
| GM-Tg-bovg-SE1505-Ab-1/ GM-Tg-bovg-SE1505-Ab-2 | Anti-Bovine FPGS monoclonal antibody | Bovine |
| GM-Tg-equg-SE1505-Ab-1/ GM-Tg-equg-SE1505-Ab-2 | Anti-Equine FPGS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1505-Ab-1/ GM-Tg-hg-SE1505-Ab-2; GM-Tg-rg-SE1505-Ab-1/ GM-Tg-rg-SE1505-Ab-2; GM-Tg-mg-SE1505-Ab-1/ GM-Tg-mg-SE1505-Ab-2; GM-Tg-cynog-SE1505-Ab-1/ GM-Tg-cynog-SE1505-Ab-2; GM-Tg-felg-SE1505-Ab-1/ GM-Tg-felg-SE1505-Ab-2; GM-Tg-cang-SE1505-Ab-1/ GM-Tg-cang-SE1505-Ab-2; GM-Tg-bovg-SE1505-Ab-1/ GM-Tg-bovg-SE1505-Ab-2; GM-Tg-equg-SE1505-Ab-1/ GM-Tg-equg-SE1505-Ab-2 |
| Products Name | Anti-FPGS monoclonal antibody |
| Format | mab |
| Target Name | FPGS |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FPGS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1505-Ag-1 | Recombinant multi-species FOLC/ FPGS protein |
| ORF Viral Vector | pGMLPm004990 | mouse Fpgs Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004990 | mouse Fpgs Lentivirus particle |
Target information
| Target ID | GM-SE1505 |
| Target Name | FPGS |
| Gene ID | 2356,14287,687266,699587,100855785,101092966,505809,100070426 |
| Gene Symbol and Synonyms | FPGS |
| Uniprot Accession | Q05932,A6H751 |
| Uniprot Entry Name | FOLC_HUMAN,FOLC_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000136877 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FPGS, gene name: FPGS, also named as . This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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