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Anti-CI072/ C9orf72/ ALSFTD functional antibody
Anti-CI072/ C9orf72/ ALSFTD functional antibody for cell culture, ELISA & in-vivo assay
Go to C9orf72/C9orf72 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1533-Ab-1/ GM-Tg-hg-SE1533-Ab-2 | Anti-Human C9orf72 monoclonal antibody | Human |
| GM-Tg-rg-SE1533-Ab-1/ GM-Tg-rg-SE1533-Ab-2 | Anti-Rat C9orf72 monoclonal antibody | Rat |
| GM-Tg-mg-SE1533-Ab-1/ GM-Tg-mg-SE1533-Ab-2 | Anti-Mouse C9orf72 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1533-Ab-1/ GM-Tg-cynog-SE1533-Ab-2 | Anti-Cynomolgus/ Rhesus macaque C9orf72 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1533-Ab-1/ GM-Tg-felg-SE1533-Ab-2 | Anti-Feline C9orf72 monoclonal antibody | Feline |
| GM-Tg-cang-SE1533-Ab-1/ GM-Tg-cang-SE1533-Ab-2 | Anti-Canine C9orf72 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1533-Ab-1/ GM-Tg-bovg-SE1533-Ab-2 | Anti-Bovine C9orf72 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1533-Ab-1/ GM-Tg-equg-SE1533-Ab-2 | Anti-Equine C9orf72 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1533-Ab-1/ GM-Tg-hg-SE1533-Ab-2; GM-Tg-rg-SE1533-Ab-1/ GM-Tg-rg-SE1533-Ab-2; GM-Tg-mg-SE1533-Ab-1/ GM-Tg-mg-SE1533-Ab-2; GM-Tg-cynog-SE1533-Ab-1/ GM-Tg-cynog-SE1533-Ab-2; GM-Tg-felg-SE1533-Ab-1/ GM-Tg-felg-SE1533-Ab-2; GM-Tg-cang-SE1533-Ab-1/ GM-Tg-cang-SE1533-Ab-2; GM-Tg-bovg-SE1533-Ab-1/ GM-Tg-bovg-SE1533-Ab-2; GM-Tg-equg-SE1533-Ab-1/ GM-Tg-equg-SE1533-Ab-2 |
| Products Name | Anti-C9orf72 monoclonal antibody |
| Format | mab |
| Target Name | C9orf72 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-C9orf72 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1533-Ag-1 | Recombinant multi-species CI072/ C9orf72/ ALSFTD protein |
| ORF Viral Vector | pGMLPm002527 | mouse 3110043O21Rik Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002527 | mouse 3110043O21Rik Lentivirus particle |
Target information
| Target ID | GM-SE1533 |
| Target Name | C9orf72 |
| Gene ID | 203228,73205,313155,706828,481569,101094546,506309,100053503 |
| Gene Symbol and Synonyms | 3110043O21Rik,ALSFTD,C11H9orf72,C15H9orf72,C23H9orf72,C8H9orf72,C9orf72,CD4H9orf72,DENND9,DENNL72,FTDALS,FTDALS1,RGD1359108 |
| Uniprot Accession | Q96LT7,Q66HC3 |
| Uniprot Entry Name | CI072_HUMAN,CI072_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000147894 |
| Target Classification | N/A |
The target: C9orf72, gene name: C9orf72, also named as ALSFTD, DENNL72, FTDALS, FTDALS1. The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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