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Anti-DHE3/ GLUD1/ GDH functional antibody
Anti-DHE3/ GLUD1/ GDH functional antibody for cell culture, ELISA & in-vivo assay
Go to GLUD1/GLUD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1537-Ab-1/ GM-Tg-hg-SE1537-Ab-2 | Anti-Human GLUD1 monoclonal antibody | Human |
| GM-Tg-rg-SE1537-Ab-1/ GM-Tg-rg-SE1537-Ab-2 | Anti-Rat GLUD1 monoclonal antibody | Rat |
| GM-Tg-mg-SE1537-Ab-1/ GM-Tg-mg-SE1537-Ab-2 | Anti-Mouse GLUD1 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1537-Ab-1/ GM-Tg-cynog-SE1537-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GLUD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1537-Ab-1/ GM-Tg-felg-SE1537-Ab-2 | Anti-Feline GLUD1 monoclonal antibody | Feline |
| GM-Tg-cang-SE1537-Ab-1/ GM-Tg-cang-SE1537-Ab-2 | Anti-Canine GLUD1 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1537-Ab-1/ GM-Tg-bovg-SE1537-Ab-2 | Anti-Bovine GLUD1 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1537-Ab-1/ GM-Tg-equg-SE1537-Ab-2 | Anti-Equine GLUD1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1537-Ab-1/ GM-Tg-hg-SE1537-Ab-2; GM-Tg-rg-SE1537-Ab-1/ GM-Tg-rg-SE1537-Ab-2; GM-Tg-mg-SE1537-Ab-1/ GM-Tg-mg-SE1537-Ab-2; GM-Tg-cynog-SE1537-Ab-1/ GM-Tg-cynog-SE1537-Ab-2; GM-Tg-felg-SE1537-Ab-1/ GM-Tg-felg-SE1537-Ab-2; GM-Tg-cang-SE1537-Ab-1/ GM-Tg-cang-SE1537-Ab-2; GM-Tg-bovg-SE1537-Ab-1/ GM-Tg-bovg-SE1537-Ab-2; GM-Tg-equg-SE1537-Ab-1/ GM-Tg-equg-SE1537-Ab-2 |
| Products Name | Anti-GLUD1 monoclonal antibody |
| Format | mab |
| Target Name | GLUD1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GLUD1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1537-Ag-1 | Recombinant multi-species DHE3/ GLUD1/ GDH protein |
Target information
| Target ID | GM-SE1537 |
| Target Name | GLUD1 |
| Gene ID | 2746,14661,24399,693461,100684847,101090049,281785,100064139 |
| Gene Symbol and Synonyms | Ac2-281,GDH,GDH 1,Gdh-X,GDH1,GLUD,GLUD1,Gludeha,Gludl,hGDH1,MRG-2 |
| Uniprot Accession | P00367,P10860,P00366 |
| Uniprot Entry Name | DHE3_HUMAN,DHE3_RAT,DHE3_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000148672 |
| Target Classification | N/A |
The target: GLUD1, gene name: GLUD1, also named as GDH, GDH1, GLUD. This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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