Anti-P4HA3 functional antibody

Anti-P4HA3 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to P4HA3/P4HA3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1538-Ab-1/ GM-Tg-hg-SE1538-Ab-2Anti-Human P4HA3 monoclonal antibodyHuman
GM-Tg-rg-SE1538-Ab-1/ GM-Tg-rg-SE1538-Ab-2Anti-Rat P4HA3 monoclonal antibodyRat
GM-Tg-mg-SE1538-Ab-1/ GM-Tg-mg-SE1538-Ab-2Anti-Mouse P4HA3 monoclonal antibodyMouse
GM-Tg-cynog-SE1538-Ab-1/ GM-Tg-cynog-SE1538-Ab-2Anti-Cynomolgus/ Rhesus macaque P4HA3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1538-Ab-1/ GM-Tg-felg-SE1538-Ab-2Anti-Feline P4HA3 monoclonal antibodyFeline
GM-Tg-cang-SE1538-Ab-1/ GM-Tg-cang-SE1538-Ab-2Anti-Canine P4HA3 monoclonal antibodyCanine
GM-Tg-bovg-SE1538-Ab-1/ GM-Tg-bovg-SE1538-Ab-2Anti-Bovine P4HA3 monoclonal antibodyBovine
GM-Tg-equg-SE1538-Ab-1/ GM-Tg-equg-SE1538-Ab-2Anti-Equine P4HA3 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1538-Ab-1/ GM-Tg-hg-SE1538-Ab-2; GM-Tg-rg-SE1538-Ab-1/ GM-Tg-rg-SE1538-Ab-2;
GM-Tg-mg-SE1538-Ab-1/ GM-Tg-mg-SE1538-Ab-2; GM-Tg-cynog-SE1538-Ab-1/ GM-Tg-cynog-SE1538-Ab-2;
GM-Tg-felg-SE1538-Ab-1/ GM-Tg-felg-SE1538-Ab-2; GM-Tg-cang-SE1538-Ab-1/ GM-Tg-cang-SE1538-Ab-2;
GM-Tg-bovg-SE1538-Ab-1/ GM-Tg-bovg-SE1538-Ab-2; GM-Tg-equg-SE1538-Ab-1/ GM-Tg-equg-SE1538-Ab-2
Products NameAnti-P4HA3 monoclonal antibody
Formatmab
Target NameP4HA3
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-P4HA3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1538-Ag-1Recombinant multi-species P4HA3 protein


    Target information

    Target IDGM-SE1538
    Target NameP4HA3
    Gene ID283208,320452,361612,718872,609381,101081160,414348,100065260
    Gene Symbol and SynonymsD930031A02Rik,P4HA3
    Uniprot AccessionQ7Z4N8,Q6W3E9,Q75UG4
    Uniprot Entry NameP4HA3_HUMAN,P4HA3_RAT,P4HA3_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000149380
    Target ClassificationN/A

    The target: P4HA3, gene name: P4HA3, also named as . This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.