Anti-DPOLL/ POLL/ BETAN functional antibody

Anti-DPOLL/ POLL/ BETAN functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to POLL/POLL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1573-Ab-1/ GM-Tg-hg-SE1573-Ab-2Anti-Human POLL monoclonal antibodyHuman
GM-Tg-rg-SE1573-Ab-1/ GM-Tg-rg-SE1573-Ab-2Anti-Rat POLL monoclonal antibodyRat
GM-Tg-mg-SE1573-Ab-1/ GM-Tg-mg-SE1573-Ab-2Anti-Mouse POLL monoclonal antibodyMouse
GM-Tg-cynog-SE1573-Ab-1/ GM-Tg-cynog-SE1573-Ab-2Anti-Cynomolgus/ Rhesus macaque POLL monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1573-Ab-1/ GM-Tg-felg-SE1573-Ab-2Anti-Feline POLL monoclonal antibodyFeline
GM-Tg-cang-SE1573-Ab-1/ GM-Tg-cang-SE1573-Ab-2Anti-Canine POLL monoclonal antibodyCanine
GM-Tg-bovg-SE1573-Ab-1/ GM-Tg-bovg-SE1573-Ab-2Anti-Bovine POLL monoclonal antibodyBovine
GM-Tg-equg-SE1573-Ab-1/ GM-Tg-equg-SE1573-Ab-2Anti-Equine POLL monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1573-Ab-1/ GM-Tg-hg-SE1573-Ab-2; GM-Tg-rg-SE1573-Ab-1/ GM-Tg-rg-SE1573-Ab-2;
GM-Tg-mg-SE1573-Ab-1/ GM-Tg-mg-SE1573-Ab-2; GM-Tg-cynog-SE1573-Ab-1/ GM-Tg-cynog-SE1573-Ab-2;
GM-Tg-felg-SE1573-Ab-1/ GM-Tg-felg-SE1573-Ab-2; GM-Tg-cang-SE1573-Ab-1/ GM-Tg-cang-SE1573-Ab-2;
GM-Tg-bovg-SE1573-Ab-1/ GM-Tg-bovg-SE1573-Ab-2; GM-Tg-equg-SE1573-Ab-1/ GM-Tg-equg-SE1573-Ab-2
Products NameAnti-POLL monoclonal antibody
Formatmab
Target NamePOLL
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-POLL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1573-Ag-1Recombinant multi-species DPOLL/ POLL/ BETAN protein


    Target information

    Target IDGM-SE1573
    Target NamePOLL
    Gene ID27343,56626,361767,711924,608341,101084138,522307,100070125
    Gene Symbol and Synonyms1110003P06Rik,BETAN,POLKAPPA,POLL
    Uniprot AccessionQ9UGP5,Q5RKI3
    Uniprot Entry NameDPOLL_HUMAN,DPOLL_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000166169
    Target ClassificationN/A

    The target: POLL, gene name: POLL, also named as BETAN, POLKAPPA. This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.