- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-CLPX/ EPP2 functional antibody
Anti-CLPX/ EPP2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CLPX/CLPX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1576-Ab-1/ GM-Tg-hg-SE1576-Ab-2 | Anti-Human CLPX monoclonal antibody | Human |
| GM-Tg-rg-SE1576-Ab-1/ GM-Tg-rg-SE1576-Ab-2 | Anti-Rat CLPX monoclonal antibody | Rat |
| GM-Tg-mg-SE1576-Ab-1/ GM-Tg-mg-SE1576-Ab-2 | Anti-Mouse CLPX monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1576-Ab-1/ GM-Tg-cynog-SE1576-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLPX monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1576-Ab-1/ GM-Tg-felg-SE1576-Ab-2 | Anti-Feline CLPX monoclonal antibody | Feline |
| GM-Tg-cang-SE1576-Ab-1/ GM-Tg-cang-SE1576-Ab-2 | Anti-Canine CLPX monoclonal antibody | Canine |
| GM-Tg-bovg-SE1576-Ab-1/ GM-Tg-bovg-SE1576-Ab-2 | Anti-Bovine CLPX monoclonal antibody | Bovine |
| GM-Tg-equg-SE1576-Ab-1/ GM-Tg-equg-SE1576-Ab-2 | Anti-Equine CLPX monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1576-Ab-1/ GM-Tg-hg-SE1576-Ab-2; GM-Tg-rg-SE1576-Ab-1/ GM-Tg-rg-SE1576-Ab-2; GM-Tg-mg-SE1576-Ab-1/ GM-Tg-mg-SE1576-Ab-2; GM-Tg-cynog-SE1576-Ab-1/ GM-Tg-cynog-SE1576-Ab-2; GM-Tg-felg-SE1576-Ab-1/ GM-Tg-felg-SE1576-Ab-2; GM-Tg-cang-SE1576-Ab-1/ GM-Tg-cang-SE1576-Ab-2; GM-Tg-bovg-SE1576-Ab-1/ GM-Tg-bovg-SE1576-Ab-2; GM-Tg-equg-SE1576-Ab-1/ GM-Tg-equg-SE1576-Ab-2 |
| Products Name | Anti-CLPX monoclonal antibody |
| Format | mab |
| Target Name | CLPX |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLPX benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1576-Ag-1 | Recombinant multi-species CLPX/ EPP2 protein |
Target information
| Target ID | GM-SE1576 |
| Target Name | CLPX |
| Gene ID | 10845,270166,300786,708954,609344,101085043,100138870,100053389 |
| Gene Symbol and Synonyms | CLPX,E330029I21,EPP2 |
| Uniprot Accession | O76031,Q5U2U0 |
| Uniprot Entry Name | CLPX_HUMAN,CLPX_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000166855 |
| Target Classification | N/A |
The target: CLPX, gene name: CLPX, also named as EPP2. The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
