Anti-NUCG/ ENDOG functional antibody

Anti-NUCG/ ENDOG functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to ENDOG/ENDOG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1580-Ab-1/ GM-Tg-hg-SE1580-Ab-2Anti-Human ENDOG monoclonal antibodyHuman
GM-Tg-rg-SE1580-Ab-1/ GM-Tg-rg-SE1580-Ab-2Anti-Rat ENDOG monoclonal antibodyRat
GM-Tg-mg-SE1580-Ab-1/ GM-Tg-mg-SE1580-Ab-2Anti-Mouse ENDOG monoclonal antibodyMouse
GM-Tg-cynog-SE1580-Ab-1/ GM-Tg-cynog-SE1580-Ab-2Anti-Cynomolgus/ Rhesus macaque ENDOG monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1580-Ab-1/ GM-Tg-felg-SE1580-Ab-2Anti-Feline ENDOG monoclonal antibodyFeline
GM-Tg-cang-SE1580-Ab-1/ GM-Tg-cang-SE1580-Ab-2Anti-Canine ENDOG monoclonal antibodyCanine
GM-Tg-bovg-SE1580-Ab-1/ GM-Tg-bovg-SE1580-Ab-2Anti-Bovine ENDOG monoclonal antibodyBovine
GM-Tg-equg-SE1580-Ab-1/ GM-Tg-equg-SE1580-Ab-2Anti-Equine ENDOG monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1580-Ab-1/ GM-Tg-hg-SE1580-Ab-2; GM-Tg-rg-SE1580-Ab-1/ GM-Tg-rg-SE1580-Ab-2;
GM-Tg-mg-SE1580-Ab-1/ GM-Tg-mg-SE1580-Ab-2; GM-Tg-cynog-SE1580-Ab-1/ GM-Tg-cynog-SE1580-Ab-2;
GM-Tg-felg-SE1580-Ab-1/ GM-Tg-felg-SE1580-Ab-2; GM-Tg-cang-SE1580-Ab-1/ GM-Tg-cang-SE1580-Ab-2;
GM-Tg-bovg-SE1580-Ab-1/ GM-Tg-bovg-SE1580-Ab-2; GM-Tg-equg-SE1580-Ab-1/ GM-Tg-equg-SE1580-Ab-2
Products NameAnti-ENDOG monoclonal antibody
Formatmab
Target NameENDOG
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ENDOG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1580-Ag-1Recombinant multi-species NUCG/ ENDOG protein


    Target information

    Target IDGM-SE1580
    Target NameENDOG
    Gene ID2021,13804,362100,717171,608916,768264,327707,100146415
    Gene Symbol and SynonymsENDOG
    Uniprot AccessionQ14249,P38447
    Uniprot Entry NameNUCG_HUMAN,NUCG_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000167136
    Target ClassificationN/A

    The target: ENDOG, gene name: ENDOG, also named as . The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.