Anti-NALP5/ NLRP5/ CLR19.8 functional antibody

Anti-NALP5/ NLRP5/ CLR19.8 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to NLRP5/NLRP5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1596-Ab-1/ GM-Tg-hg-SE1596-Ab-2Anti-Human NLRP5 monoclonal antibodyHuman
GM-Tg-rg-SE1596-Ab-1/ GM-Tg-rg-SE1596-Ab-2Anti-Rat NLRP5 monoclonal antibodyRat
GM-Tg-mg-SE1596-Ab-1/ GM-Tg-mg-SE1596-Ab-2Anti-Mouse NLRP5 monoclonal antibodyMouse
GM-Tg-cynog-SE1596-Ab-1/ GM-Tg-cynog-SE1596-Ab-2Anti-Cynomolgus/ Rhesus macaque NLRP5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1596-Ab-1/ GM-Tg-felg-SE1596-Ab-2Anti-Feline NLRP5 monoclonal antibodyFeline
GM-Tg-cang-SE1596-Ab-1/ GM-Tg-cang-SE1596-Ab-2Anti-Canine NLRP5 monoclonal antibodyCanine
GM-Tg-bovg-SE1596-Ab-1/ GM-Tg-bovg-SE1596-Ab-2Anti-Bovine NLRP5 monoclonal antibodyBovine
GM-Tg-equg-SE1596-Ab-1/ GM-Tg-equg-SE1596-Ab-2Anti-Equine NLRP5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1596-Ab-1/ GM-Tg-hg-SE1596-Ab-2; GM-Tg-rg-SE1596-Ab-1/ GM-Tg-rg-SE1596-Ab-2;
GM-Tg-mg-SE1596-Ab-1/ GM-Tg-mg-SE1596-Ab-2; GM-Tg-cynog-SE1596-Ab-1/ GM-Tg-cynog-SE1596-Ab-2;
GM-Tg-felg-SE1596-Ab-1/ GM-Tg-felg-SE1596-Ab-2; GM-Tg-cang-SE1596-Ab-1/ GM-Tg-cang-SE1596-Ab-2;
GM-Tg-bovg-SE1596-Ab-1/ GM-Tg-bovg-SE1596-Ab-2; GM-Tg-equg-SE1596-Ab-1/ GM-Tg-equg-SE1596-Ab-2
Products NameAnti-NLRP5 monoclonal antibody
Formatmab
Target NameNLRP5
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NLRP5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1596-Ag-1Recombinant multi-species NALP5/ NLRP5/ CLR19.8 protein


    Target information

    Target IDGM-SE1596
    Target NameNLRP5
    Gene ID126206,23968,308325,704276,476373,101081176,493717,100057440
    Gene Symbol and SynonymsCLR19.8,MATER,NALP5,NLRP5,Op1,OZEMA19,PAN11,PYPAF8
    Uniprot AccessionP59047,Q647I9
    Uniprot Entry NameNALP5_HUMAN,NALP5_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000171487
    Target ClassificationN/A

    The target: NLRP5, gene name: NLRP5, also named as CLR19.8, MATER, NALP5, PAN11, PYPAF8. The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.