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Anti-EST3/ CES3/ ES31 functional antibody
Anti-EST3/ CES3/ ES31 functional antibody for cell culture, ELISA & in-vivo assay
Go to CES3/CES3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1602-Ab-1/ GM-Tg-hg-SE1602-Ab-2 | Anti-Human CES3 monoclonal antibody | Human |
| GM-Tg-rg-SE1602-Ab-1/ GM-Tg-rg-SE1602-Ab-2 | Anti-Rat CES3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1602-Ab-1/ GM-Tg-mg-SE1602-Ab-2 | Anti-Mouse CES3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1602-Ab-1/ GM-Tg-cynog-SE1602-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CES3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1602-Ab-1/ GM-Tg-felg-SE1602-Ab-2 | Anti-Feline CES3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1602-Ab-1/ GM-Tg-cang-SE1602-Ab-2 | Anti-Canine CES3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1602-Ab-1/ GM-Tg-bovg-SE1602-Ab-2 | Anti-Bovine CES3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1602-Ab-1/ GM-Tg-equg-SE1602-Ab-2 | Anti-Equine CES3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1602-Ab-1/ GM-Tg-hg-SE1602-Ab-2; GM-Tg-rg-SE1602-Ab-1/ GM-Tg-rg-SE1602-Ab-2; GM-Tg-mg-SE1602-Ab-1/ GM-Tg-mg-SE1602-Ab-2; GM-Tg-cynog-SE1602-Ab-1/ GM-Tg-cynog-SE1602-Ab-2; GM-Tg-felg-SE1602-Ab-1/ GM-Tg-felg-SE1602-Ab-2; GM-Tg-cang-SE1602-Ab-1/ GM-Tg-cang-SE1602-Ab-2; GM-Tg-bovg-SE1602-Ab-1/ GM-Tg-bovg-SE1602-Ab-2; GM-Tg-equg-SE1602-Ab-1/ GM-Tg-equg-SE1602-Ab-2 |
| Products Name | Anti-CES3 monoclonal antibody |
| Format | mab |
| Target Name | CES3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CES3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1602-Ag-1 | Recombinant multi-species EST3/ CES3/ ES31 protein |
Target information
| Target ID | GM-SE1602 |
| Target Name | CES3 |
| Gene ID | 23491,13909,689754,101097032,513112 |
| Gene Symbol and Synonyms | CES3,Ces3-ps1,Ces31L,Ces3a,Ces3b,Ces3L,EG13909,ES31,ES31L,Gm4738 |
| Uniprot Accession | Q6UWW8 |
| Uniprot Entry Name | EST3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000172828 |
| Target Classification | N/A |
The target: CES3, gene name: CES3, also named as ES31. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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