Anti-MGAP/ MGA/ MAD5 functional antibody

Anti-MGAP/ MGA/ MAD5 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to MGA/MGA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1608-Ab-1/ GM-Tg-hg-SE1608-Ab-2Anti-Human MGA monoclonal antibodyHuman
GM-Tg-rg-SE1608-Ab-1/ GM-Tg-rg-SE1608-Ab-2Anti-Rat MGA monoclonal antibodyRat
GM-Tg-mg-SE1608-Ab-1/ GM-Tg-mg-SE1608-Ab-2Anti-Mouse MGA monoclonal antibodyMouse
GM-Tg-cynog-SE1608-Ab-1/ GM-Tg-cynog-SE1608-Ab-2Anti-Cynomolgus/ Rhesus macaque MGA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1608-Ab-1/ GM-Tg-felg-SE1608-Ab-2Anti-Feline MGA monoclonal antibodyFeline
GM-Tg-cang-SE1608-Ab-1/ GM-Tg-cang-SE1608-Ab-2Anti-Canine MGA monoclonal antibodyCanine
GM-Tg-bovg-SE1608-Ab-1/ GM-Tg-bovg-SE1608-Ab-2Anti-Bovine MGA monoclonal antibodyBovine
GM-Tg-equg-SE1608-Ab-1/ GM-Tg-equg-SE1608-Ab-2Anti-Equine MGA monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1608-Ab-1/ GM-Tg-hg-SE1608-Ab-2; GM-Tg-rg-SE1608-Ab-1/ GM-Tg-rg-SE1608-Ab-2;
GM-Tg-mg-SE1608-Ab-1/ GM-Tg-mg-SE1608-Ab-2; GM-Tg-cynog-SE1608-Ab-1/ GM-Tg-cynog-SE1608-Ab-2;
GM-Tg-felg-SE1608-Ab-1/ GM-Tg-felg-SE1608-Ab-2; GM-Tg-cang-SE1608-Ab-1/ GM-Tg-cang-SE1608-Ab-2;
GM-Tg-bovg-SE1608-Ab-1/ GM-Tg-bovg-SE1608-Ab-2; GM-Tg-equg-SE1608-Ab-1/ GM-Tg-equg-SE1608-Ab-2
Products NameAnti-MGA monoclonal antibody
Formatmab
Target NameMGA
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MGA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1608-Ag-1Recombinant multi-species MGAP/ MGA/ MAD5 protein


    Target information

    Target IDGM-SE1608
    Target NameMGA
    Gene ID23269,29808,499874,706849,478266,101084202,532556,100056831
    Gene Symbol and SynonymsC130042M01Rik,D030062C11Rik,MAD5,MGA,MXD5,RGD1561597
    Uniprot AccessionQ8IWI9
    Uniprot Entry NameMGAP_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000174197
    Target ClassificationN/A

    The target: MGA, gene name: MGA, also named as MAD5, MXD5. Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.