Anti-FUCO/ FUCA1/ FUCA functional antibody

Anti-FUCO/ FUCA1/ FUCA functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to FUCA1/FUCA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1623-Ab-1/ GM-Tg-hg-SE1623-Ab-2Anti-Human FUCA1 monoclonal antibodyHuman
GM-Tg-rg-SE1623-Ab-1/ GM-Tg-rg-SE1623-Ab-2Anti-Rat FUCA1 monoclonal antibodyRat
GM-Tg-mg-SE1623-Ab-1/ GM-Tg-mg-SE1623-Ab-2Anti-Mouse FUCA1 monoclonal antibodyMouse
GM-Tg-cynog-SE1623-Ab-1/ GM-Tg-cynog-SE1623-Ab-2Anti-Cynomolgus/ Rhesus macaque FUCA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1623-Ab-1/ GM-Tg-felg-SE1623-Ab-2Anti-Feline FUCA1 monoclonal antibodyFeline
GM-Tg-cang-SE1623-Ab-1/ GM-Tg-cang-SE1623-Ab-2Anti-Canine FUCA1 monoclonal antibodyCanine
GM-Tg-bovg-SE1623-Ab-1/ GM-Tg-bovg-SE1623-Ab-2Anti-Bovine FUCA1 monoclonal antibodyBovine
GM-Tg-equg-SE1623-Ab-1/ GM-Tg-equg-SE1623-Ab-2Anti-Equine FUCA1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1623-Ab-1/ GM-Tg-hg-SE1623-Ab-2; GM-Tg-rg-SE1623-Ab-1/ GM-Tg-rg-SE1623-Ab-2;
GM-Tg-mg-SE1623-Ab-1/ GM-Tg-mg-SE1623-Ab-2; GM-Tg-cynog-SE1623-Ab-1/ GM-Tg-cynog-SE1623-Ab-2;
GM-Tg-felg-SE1623-Ab-1/ GM-Tg-felg-SE1623-Ab-2; GM-Tg-cang-SE1623-Ab-1/ GM-Tg-cang-SE1623-Ab-2;
GM-Tg-bovg-SE1623-Ab-1/ GM-Tg-bovg-SE1623-Ab-2; GM-Tg-equg-SE1623-Ab-1/ GM-Tg-equg-SE1623-Ab-2
Products NameAnti-FUCA1 monoclonal antibody
Formatmab
Target NameFUCA1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FUCA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1623-Ag-1Recombinant multi-species FUCO/ FUCA1/ FUCA protein
    ORF Viral VectorpGMLPm004914mouse Fuca1 Lentivirus plasmid
    ORF Viral VectorvGMLPm004914mouse Fuca1 Lentivirus particle


    Target information

    Target IDGM-SE1623
    Target NameFUCA1
    Gene ID2517,71665,24375,710993,403929,101099988,509522,100071543
    Gene Symbol and Synonyms0610006A03Rik,9530055J05Rik,Afuc,FUCA,FUCA1
    Uniprot AccessionP04066,P17164,P48300,Q2KIM0
    Uniprot Entry NameFUCO_HUMAN,FUCO_RAT,FUCO_CANLF,FUCO_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000179163
    Target ClassificationN/A

    The target: FUCA1, gene name: FUCA1, also named as FUCA. The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.