Anti-NGRN/ DSC92 functional antibody

Anti-NGRN/ DSC92 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to NGRN/NGRN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1629-Ab-1/ GM-Tg-hg-SE1629-Ab-2Anti-Human NGRN monoclonal antibodyHuman
GM-Tg-rg-SE1629-Ab-1/ GM-Tg-rg-SE1629-Ab-2Anti-Rat NGRN monoclonal antibodyRat
GM-Tg-mg-SE1629-Ab-1/ GM-Tg-mg-SE1629-Ab-2Anti-Mouse NGRN monoclonal antibodyMouse
GM-Tg-cynog-SE1629-Ab-1/ GM-Tg-cynog-SE1629-Ab-2Anti-Cynomolgus/ Rhesus macaque NGRN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1629-Ab-1/ GM-Tg-felg-SE1629-Ab-2Anti-Feline NGRN monoclonal antibodyFeline
GM-Tg-cang-SE1629-Ab-1/ GM-Tg-cang-SE1629-Ab-2Anti-Canine NGRN monoclonal antibodyCanine
GM-Tg-bovg-SE1629-Ab-1/ GM-Tg-bovg-SE1629-Ab-2Anti-Bovine NGRN monoclonal antibodyBovine
GM-Tg-equg-SE1629-Ab-1/ GM-Tg-equg-SE1629-Ab-2Anti-Equine NGRN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1629-Ab-1/ GM-Tg-hg-SE1629-Ab-2; GM-Tg-rg-SE1629-Ab-1/ GM-Tg-rg-SE1629-Ab-2;
GM-Tg-mg-SE1629-Ab-1/ GM-Tg-mg-SE1629-Ab-2; GM-Tg-cynog-SE1629-Ab-1/ GM-Tg-cynog-SE1629-Ab-2;
GM-Tg-felg-SE1629-Ab-1/ GM-Tg-felg-SE1629-Ab-2; GM-Tg-cang-SE1629-Ab-1/ GM-Tg-cang-SE1629-Ab-2;
GM-Tg-bovg-SE1629-Ab-1/ GM-Tg-bovg-SE1629-Ab-2; GM-Tg-equg-SE1629-Ab-1/ GM-Tg-equg-SE1629-Ab-2
Products NameAnti-NGRN monoclonal antibody
Formatmab
Target NameNGRN
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NGRN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1629-Ag-1Recombinant multi-species NGRN/ DSC92 protein


    Target information

    Target IDGM-SE1629
    Target NameNGRN
    Gene ID51335,83485,499191,702187,100684886,101081549,508115,100053531
    Gene Symbol and SynonymsDSC92,Neugrin,NGRN
    Uniprot AccessionQ9NPE2,Q3T1H2,Q2HJC0
    Uniprot Entry NameNGRN_HUMAN,NGRN_RAT,NGRN_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000182768
    Target ClassificationN/A

    The target: NGRN, gene name: NGRN, also named as DSC92. Enables rRNA binding activity. Involved in positive regulation of mitochondrial translation. Located in several cellular components, including intercellular bridge; mitotic spindle; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.