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Anti-SEP15/ SELENOF/15-Sep functional antibody
Anti-SEP15/ SELENOF/15-Sep functional antibody for cell culture, ELISA & in-vivo assay
Go to SELENOF/SELENOF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1631-Ab-1/ GM-Tg-hg-SE1631-Ab-2 | Anti-Human SELENOF monoclonal antibody | Human |
| GM-Tg-rg-SE1631-Ab-1/ GM-Tg-rg-SE1631-Ab-2 | Anti-Rat SELENOF monoclonal antibody | Rat |
| GM-Tg-mg-SE1631-Ab-1/ GM-Tg-mg-SE1631-Ab-2 | Anti-Mouse SELENOF monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1631-Ab-1/ GM-Tg-cynog-SE1631-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SELENOF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1631-Ab-1/ GM-Tg-felg-SE1631-Ab-2 | Anti-Feline SELENOF monoclonal antibody | Feline |
| GM-Tg-cang-SE1631-Ab-1/ GM-Tg-cang-SE1631-Ab-2 | Anti-Canine SELENOF monoclonal antibody | Canine |
| GM-Tg-bovg-SE1631-Ab-1/ GM-Tg-bovg-SE1631-Ab-2 | Anti-Bovine SELENOF monoclonal antibody | Bovine |
| GM-Tg-equg-SE1631-Ab-1/ GM-Tg-equg-SE1631-Ab-2 | Anti-Equine SELENOF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1631-Ab-1/ GM-Tg-hg-SE1631-Ab-2; GM-Tg-rg-SE1631-Ab-1/ GM-Tg-rg-SE1631-Ab-2; GM-Tg-mg-SE1631-Ab-1/ GM-Tg-mg-SE1631-Ab-2; GM-Tg-cynog-SE1631-Ab-1/ GM-Tg-cynog-SE1631-Ab-2; GM-Tg-felg-SE1631-Ab-1/ GM-Tg-felg-SE1631-Ab-2; GM-Tg-cang-SE1631-Ab-1/ GM-Tg-cang-SE1631-Ab-2; GM-Tg-bovg-SE1631-Ab-1/ GM-Tg-bovg-SE1631-Ab-2; GM-Tg-equg-SE1631-Ab-1/ GM-Tg-equg-SE1631-Ab-2 |
| Products Name | Anti-SELENOF monoclonal antibody |
| Format | mab |
| Target Name | SELENOF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SELENOF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1631-Ag-1 | Recombinant multi-species SEP15/ SELENOF/15-Sep protein |
Target information
| Target ID | GM-SE1631 |
| Target Name | SELENOF |
| Gene ID | 9403,93684,113922,712469,612493,101080311,614360,100052383 |
| Gene Symbol and Synonyms | 9430015P09Rik,SELENOF,SEP15 |
| Uniprot Accession | O60613,Q923V8,A8YXY3 |
| Uniprot Entry Name | SEP15_HUMAN,SEP15_RAT,SEP15_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000183291 |
| Target Classification | N/A |
The target: SELENOF, gene name: SELENOF, also named as SEP15. The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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