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Anti-SEBP2/ SECISBP2/ SBP2 functional antibody
Anti-SEBP2/ SECISBP2/ SBP2 functional antibody for cell culture, ELISA & in-vivo assay
Go to SECISBP2/SECISBP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1640-Ab-1/ GM-Tg-hg-SE1640-Ab-2 | Anti-Human SECISBP2 monoclonal antibody | Human |
| GM-Tg-rg-SE1640-Ab-1/ GM-Tg-rg-SE1640-Ab-2 | Anti-Rat SECISBP2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1640-Ab-1/ GM-Tg-mg-SE1640-Ab-2 | Anti-Mouse SECISBP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1640-Ab-1/ GM-Tg-cynog-SE1640-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SECISBP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1640-Ab-1/ GM-Tg-felg-SE1640-Ab-2 | Anti-Feline SECISBP2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1640-Ab-1/ GM-Tg-cang-SE1640-Ab-2 | Anti-Canine SECISBP2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1640-Ab-1/ GM-Tg-bovg-SE1640-Ab-2 | Anti-Bovine SECISBP2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1640-Ab-1/ GM-Tg-equg-SE1640-Ab-2 | Anti-Equine SECISBP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1640-Ab-1/ GM-Tg-hg-SE1640-Ab-2; GM-Tg-rg-SE1640-Ab-1/ GM-Tg-rg-SE1640-Ab-2; GM-Tg-mg-SE1640-Ab-1/ GM-Tg-mg-SE1640-Ab-2; GM-Tg-cynog-SE1640-Ab-1/ GM-Tg-cynog-SE1640-Ab-2; GM-Tg-felg-SE1640-Ab-1/ GM-Tg-felg-SE1640-Ab-2; GM-Tg-cang-SE1640-Ab-1/ GM-Tg-cang-SE1640-Ab-2; GM-Tg-bovg-SE1640-Ab-1/ GM-Tg-bovg-SE1640-Ab-2; GM-Tg-equg-SE1640-Ab-1/ GM-Tg-equg-SE1640-Ab-2 |
| Products Name | Anti-SECISBP2 monoclonal antibody |
| Format | mab |
| Target Name | SECISBP2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SECISBP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1640-Ag-1 | Recombinant multi-species SEBP2/ SECISBP2/ SBP2 protein |
Target information
| Target ID | GM-SE1640 |
| Target Name | SECISBP2 |
| Gene ID | 79048,75420,79049,697442,476351,101096115,511202,100062130 |
| Gene Symbol and Synonyms | 2210413N07Rik,2810012K13Rik,SBP2,SECISBP2,THMA1 |
| Uniprot Accession | Q96T21,Q9QX72 |
| Uniprot Entry Name | SEBP2_HUMAN,SEBP2_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000187742 |
| Target Classification | N/A |
The target: SECISBP2, gene name: SECISBP2, also named as SBP2. The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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