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Anti-RM21/ MRPL21/ L21mt functional antibody
Anti-RM21/ MRPL21/ L21mt functional antibody for cell culture, ELISA & in-vivo assay
Go to MRPL21/MRPL21 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1644-Ab-1/ GM-Tg-hg-SE1644-Ab-2 | Anti-Human MRPL21 monoclonal antibody | Human |
| GM-Tg-rg-SE1644-Ab-1/ GM-Tg-rg-SE1644-Ab-2 | Anti-Rat MRPL21 monoclonal antibody | Rat |
| GM-Tg-mg-SE1644-Ab-1/ GM-Tg-mg-SE1644-Ab-2 | Anti-Mouse MRPL21 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1644-Ab-1/ GM-Tg-cynog-SE1644-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MRPL21 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1644-Ab-1/ GM-Tg-felg-SE1644-Ab-2 | Anti-Feline MRPL21 monoclonal antibody | Feline |
| GM-Tg-cang-SE1644-Ab-1/ GM-Tg-cang-SE1644-Ab-2 | Anti-Canine MRPL21 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1644-Ab-1/ GM-Tg-bovg-SE1644-Ab-2 | Anti-Bovine MRPL21 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1644-Ab-1/ GM-Tg-equg-SE1644-Ab-2 | Anti-Equine MRPL21 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1644-Ab-1/ GM-Tg-hg-SE1644-Ab-2; GM-Tg-rg-SE1644-Ab-1/ GM-Tg-rg-SE1644-Ab-2; GM-Tg-mg-SE1644-Ab-1/ GM-Tg-mg-SE1644-Ab-2; GM-Tg-cynog-SE1644-Ab-1/ GM-Tg-cynog-SE1644-Ab-2; GM-Tg-felg-SE1644-Ab-1/ GM-Tg-felg-SE1644-Ab-2; GM-Tg-cang-SE1644-Ab-1/ GM-Tg-cang-SE1644-Ab-2; GM-Tg-bovg-SE1644-Ab-1/ GM-Tg-bovg-SE1644-Ab-2; GM-Tg-equg-SE1644-Ab-1/ GM-Tg-equg-SE1644-Ab-2 |
| Products Name | Anti-MRPL21 monoclonal antibody |
| Format | mab |
| Target Name | MRPL21 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MRPL21 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1644-Ag-1 | Recombinant multi-species RM21/ MRPL21/ L21mt protein |
Target information
| Target ID | GM-SE1644 |
| Target Name | MRPL21 |
| Gene ID | 219927,353242,309140,114672219,101085575,618609,100053582 |
| Gene Symbol and Synonyms | L21mt,MRP-L21,MRPL21 |
| Uniprot Accession | Q7Z2W9,Q2TBS2 |
| Uniprot Entry Name | RM21_HUMAN,RM21_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000197345 |
| Target Classification | N/A |
The target: MRPL21, gene name: MRPL21, also named as L21mt, MRP-L21. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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