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Anti-CCNL2/ ANIA-6B/ CCNM functional antibody
Anti-CCNL2/ ANIA-6B/ CCNM functional antibody for cell culture, ELISA & in-vivo assay
Go to CCNL2/CCNL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1658-Ab-1/ GM-Tg-hg-SE1658-Ab-2 | Anti-Human CCNL2 monoclonal antibody | Human |
| GM-Tg-rg-SE1658-Ab-1/ GM-Tg-rg-SE1658-Ab-2 | Anti-Rat CCNL2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1658-Ab-1/ GM-Tg-mg-SE1658-Ab-2 | Anti-Mouse CCNL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1658-Ab-1/ GM-Tg-cynog-SE1658-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCNL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1658-Ab-1/ GM-Tg-felg-SE1658-Ab-2 | Anti-Feline CCNL2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1658-Ab-1/ GM-Tg-cang-SE1658-Ab-2 | Anti-Canine CCNL2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1658-Ab-1/ GM-Tg-bovg-SE1658-Ab-2 | Anti-Bovine CCNL2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1658-Ab-1/ GM-Tg-equg-SE1658-Ab-2 | Anti-Equine CCNL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1658-Ab-1/ GM-Tg-hg-SE1658-Ab-2; GM-Tg-rg-SE1658-Ab-1/ GM-Tg-rg-SE1658-Ab-2; GM-Tg-mg-SE1658-Ab-1/ GM-Tg-mg-SE1658-Ab-2; GM-Tg-cynog-SE1658-Ab-1/ GM-Tg-cynog-SE1658-Ab-2; GM-Tg-felg-SE1658-Ab-1/ GM-Tg-felg-SE1658-Ab-2; GM-Tg-cang-SE1658-Ab-1/ GM-Tg-cang-SE1658-Ab-2; GM-Tg-bovg-SE1658-Ab-1/ GM-Tg-bovg-SE1658-Ab-2; GM-Tg-equg-SE1658-Ab-1/ GM-Tg-equg-SE1658-Ab-2 |
| Products Name | Anti-CCNL2 monoclonal antibody |
| Format | mab |
| Target Name | CCNL2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCNL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1658-Ag-1 | Recombinant multi-species CCNL2/ ANIA-6B/ CCNM protein |
Target information
| Target ID | GM-SE1658 |
| Target Name | CCNL2 |
| Gene ID | 81669,56036,298686,114669744,479570,101085279,538796,100065860 |
| Gene Symbol and Synonyms | 1700010A01Rik,1810019L15Rik,2010319M22Rik,ANIA-6B,CCNL2,CCNM,CCNS,HCLA-150,HCLA-ISO,HLA-ISO,PCEE,SB138 |
| Uniprot Accession | Q96S94,Q5I0H5 |
| Uniprot Entry Name | CCNL2_HUMAN,CCNL2_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000221978 |
| Target Classification | N/A |
The target: CCNL2, gene name: CCNL2, also named as ANIA-6B, CCNM, CCNS, HCLA-ISO, HLA-ISO, PCEE, SB138. The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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