Anti-CCNL2/ ANIA-6B/ CCNM functional antibody

Anti-CCNL2/ ANIA-6B/ CCNM functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CCNL2/CCNL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1658-Ab-1/ GM-Tg-hg-SE1658-Ab-2Anti-Human CCNL2 monoclonal antibodyHuman
GM-Tg-rg-SE1658-Ab-1/ GM-Tg-rg-SE1658-Ab-2Anti-Rat CCNL2 monoclonal antibodyRat
GM-Tg-mg-SE1658-Ab-1/ GM-Tg-mg-SE1658-Ab-2Anti-Mouse CCNL2 monoclonal antibodyMouse
GM-Tg-cynog-SE1658-Ab-1/ GM-Tg-cynog-SE1658-Ab-2Anti-Cynomolgus/ Rhesus macaque CCNL2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1658-Ab-1/ GM-Tg-felg-SE1658-Ab-2Anti-Feline CCNL2 monoclonal antibodyFeline
GM-Tg-cang-SE1658-Ab-1/ GM-Tg-cang-SE1658-Ab-2Anti-Canine CCNL2 monoclonal antibodyCanine
GM-Tg-bovg-SE1658-Ab-1/ GM-Tg-bovg-SE1658-Ab-2Anti-Bovine CCNL2 monoclonal antibodyBovine
GM-Tg-equg-SE1658-Ab-1/ GM-Tg-equg-SE1658-Ab-2Anti-Equine CCNL2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1658-Ab-1/ GM-Tg-hg-SE1658-Ab-2; GM-Tg-rg-SE1658-Ab-1/ GM-Tg-rg-SE1658-Ab-2;
GM-Tg-mg-SE1658-Ab-1/ GM-Tg-mg-SE1658-Ab-2; GM-Tg-cynog-SE1658-Ab-1/ GM-Tg-cynog-SE1658-Ab-2;
GM-Tg-felg-SE1658-Ab-1/ GM-Tg-felg-SE1658-Ab-2; GM-Tg-cang-SE1658-Ab-1/ GM-Tg-cang-SE1658-Ab-2;
GM-Tg-bovg-SE1658-Ab-1/ GM-Tg-bovg-SE1658-Ab-2; GM-Tg-equg-SE1658-Ab-1/ GM-Tg-equg-SE1658-Ab-2
Products NameAnti-CCNL2 monoclonal antibody
Formatmab
Target NameCCNL2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCNL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1658-Ag-1Recombinant multi-species CCNL2/ ANIA-6B/ CCNM protein


    Target information

    Target IDGM-SE1658
    Target NameCCNL2
    Gene ID81669,56036,298686,114669744,479570,101085279,538796,100065860
    Gene Symbol and Synonyms1700010A01Rik,1810019L15Rik,2010319M22Rik,ANIA-6B,CCNL2,CCNM,CCNS,HCLA-150,HCLA-ISO,HLA-ISO,PCEE,SB138
    Uniprot AccessionQ96S94,Q5I0H5
    Uniprot Entry NameCCNL2_HUMAN,CCNL2_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseN/A
    Gene EnsemblENSG00000221978
    Target ClassificationN/A

    The target: CCNL2, gene name: CCNL2, also named as ANIA-6B, CCNM, CCNS, HCLA-ISO, HLA-ISO, PCEE, SB138. The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.