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Anti-CALR3/ CMH19/ CRT2 functional antibody
Anti-CALR3/ CMH19/ CRT2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CALR3/CALR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1671-Ab-1/ GM-Tg-hg-SE1671-Ab-2 | Anti-Human CALR3 monoclonal antibody | Human |
| GM-Tg-rg-SE1671-Ab-1/ GM-Tg-rg-SE1671-Ab-2 | Anti-Rat CALR3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1671-Ab-1/ GM-Tg-mg-SE1671-Ab-2 | Anti-Mouse CALR3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1671-Ab-1/ GM-Tg-cynog-SE1671-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CALR3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1671-Ab-1/ GM-Tg-felg-SE1671-Ab-2 | Anti-Feline CALR3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1671-Ab-1/ GM-Tg-cang-SE1671-Ab-2 | Anti-Canine CALR3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1671-Ab-1/ GM-Tg-bovg-SE1671-Ab-2 | Anti-Bovine CALR3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1671-Ab-1/ GM-Tg-equg-SE1671-Ab-2 | Anti-Equine CALR3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1671-Ab-1/ GM-Tg-hg-SE1671-Ab-2; GM-Tg-rg-SE1671-Ab-1/ GM-Tg-rg-SE1671-Ab-2; GM-Tg-mg-SE1671-Ab-1/ GM-Tg-mg-SE1671-Ab-2; GM-Tg-cynog-SE1671-Ab-1/ GM-Tg-cynog-SE1671-Ab-2; GM-Tg-felg-SE1671-Ab-1/ GM-Tg-felg-SE1671-Ab-2; GM-Tg-cang-SE1671-Ab-1/ GM-Tg-cang-SE1671-Ab-2; GM-Tg-bovg-SE1671-Ab-1/ GM-Tg-bovg-SE1671-Ab-2; GM-Tg-equg-SE1671-Ab-1/ GM-Tg-equg-SE1671-Ab-2 |
| Products Name | Anti-CALR3 monoclonal antibody |
| Format | mab |
| Target Name | CALR3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CALR3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1671-Ag-1 | Recombinant multi-species CALR3/ CMH19/ CRT2 protein |
Target information
| Target ID | GM-SE1671 |
| Target Name | CALR3 |
| Gene ID | 125972,73316,364529,719532,476680,101100949,508555,100069862 |
| Gene Symbol and Synonyms | 1700031L01Rik,6330586I20Rik,CALR3,CMH19,CRT2,cspn,CT93 |
| Uniprot Accession | Q96L12,Q2TBR8 |
| Uniprot Entry Name | CALR3_HUMAN,CALR3_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000269058 |
| Target Classification | N/A |
The target: CALR3, gene name: CALR3, also named as CMH19, CRT2, CT93. The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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