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Anti-MDM2 monoclonal antibody
Pre-made anti-MDM2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MDM2/MDM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T00176-Ab-1/ GM-Tg-hg-T00176-Ab-2 | Anti-Human MDM2 monoclonal antibody | Human |
| GM-Tg-rg-T00176-Ab-1/ GM-Tg-rg-T00176-Ab-2 | Anti-Rat MDM2 monoclonal antibody | Rat |
| GM-Tg-mg-T00176-Ab-1/ GM-Tg-mg-T00176-Ab-2 | Anti-Mouse MDM2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T00176-Ab-1/ GM-Tg-cynog-T00176-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MDM2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T00176-Ab-1/ GM-Tg-felg-T00176-Ab-2 | Anti-Feline MDM2 monoclonal antibody | Feline |
| GM-Tg-cang-T00176-Ab-1/ GM-Tg-cang-T00176-Ab-2 | Anti-Canine MDM2 monoclonal antibody | Canine |
| GM-Tg-bovg-T00176-Ab-1/ GM-Tg-bovg-T00176-Ab-2 | Anti-Bovine MDM2 monoclonal antibody | Bovine |
| GM-Tg-equg-T00176-Ab-1/ GM-Tg-equg-T00176-Ab-2 | Anti-Equine MDM2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T00176-Ab-1/ GM-Tg-hg-T00176-Ab-2; GM-Tg-rg-T00176-Ab-1/ GM-Tg-rg-T00176-Ab-2; GM-Tg-mg-T00176-Ab-1/ GM-Tg-mg-T00176-Ab-2; GM-Tg-cynog-T00176-Ab-1/ GM-Tg-cynog-T00176-Ab-2; GM-Tg-felg-T00176-Ab-1/ GM-Tg-felg-T00176-Ab-2; GM-Tg-cang-T00176-Ab-1/ GM-Tg-cang-T00176-Ab-2; GM-Tg-bovg-T00176-Ab-1/ GM-Tg-bovg-T00176-Ab-2; GM-Tg-equg-T00176-Ab-1/ GM-Tg-equg-T00176-Ab-2 |
| Products Name | Anti-MDM2 monoclonal antibody |
| Format | mab |
| Target Name | MDM2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MDM2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T00176-Ag-1 | Recombinant multi-species MDM2/ ACTFS/ HDMX protein |
| ORF Viral Vector | pGMLV000680 | human MDM2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000680 | human MDM2 Lentivirus particle |
| ORF Viral Vector | pGMLV000678 | Norway rat Mdm2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000678 | Norway rat Mdm2 Lentivirus particle |
Target information
| Target ID | GM-T00176 |
| Target Name | MDM2 |
| Gene ID | 4193,17246,314856,718284,403693,493939,540378,100052084 |
| Gene Symbol and Synonyms | 1700007J15Rik,ACTFS,edm2,hdm2,HDMX,LSKB,Mdm-2,MDM2 |
| Uniprot Accession | Q00987,P56950,Q7YRZ8,P56951 |
| Uniprot Entry Name | MDM2_HUMAN,MDM2_FELCA,MDM2_CANLF,MDM2_HORSE |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000135679 |
| Target Classification | N/A |
The target: MDM2, gene name: MDM2, also named as ACTFS, HDMX, hdm2. This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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