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Anti-GHR/ GHBP/ GHIP monoclonal antibody
Anti-GHR/ GHBP/ GHIP antibody for FACS & in-vivo assay
Go to GHR/GHR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T02333-Ab-1/ GM-Tg-hg-T02333-Ab-2 | Anti-Human GHR monoclonal antibody | Human |
| GM-Tg-rg-T02333-Ab-1/ GM-Tg-rg-T02333-Ab-2 | Anti-Rat GHR monoclonal antibody | Rat |
| GM-Tg-mg-T02333-Ab-1/ GM-Tg-mg-T02333-Ab-2 | Anti-Mouse GHR monoclonal antibody | Mouse |
| GM-Tg-cynog-T02333-Ab-1/ GM-Tg-cynog-T02333-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GHR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T02333-Ab-1/ GM-Tg-felg-T02333-Ab-2 | Anti-Feline GHR monoclonal antibody | Feline |
| GM-Tg-cang-T02333-Ab-1/ GM-Tg-cang-T02333-Ab-2 | Anti-Canine GHR monoclonal antibody | Canine |
| GM-Tg-bovg-T02333-Ab-1/ GM-Tg-bovg-T02333-Ab-2 | Anti-Bovine GHR monoclonal antibody | Bovine |
| GM-Tg-equg-T02333-Ab-1/ GM-Tg-equg-T02333-Ab-2 | Anti-Equine GHR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T02333-Ab-1/ GM-Tg-hg-T02333-Ab-2; GM-Tg-rg-T02333-Ab-1/ GM-Tg-rg-T02333-Ab-2; GM-Tg-mg-T02333-Ab-1/ GM-Tg-mg-T02333-Ab-2; GM-Tg-cynog-T02333-Ab-1/ GM-Tg-cynog-T02333-Ab-2; GM-Tg-felg-T02333-Ab-1/ GM-Tg-felg-T02333-Ab-2; GM-Tg-cang-T02333-Ab-1/ GM-Tg-cang-T02333-Ab-2; GM-Tg-bovg-T02333-Ab-1/ GM-Tg-bovg-T02333-Ab-2; GM-Tg-equg-T02333-Ab-1/ GM-Tg-equg-T02333-Ab-2 |
| Products Name | Anti-GHR monoclonal antibody |
| Format | mab |
| Target Name | GHR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GHR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-825 | |
| Biosimilar | GMP-Bios-INN-827 | Pre-Made Eftansomatropin Alfa Biosimilar, Fusion Protein targeting GHR fused with human IGHG4 Fc (Fragment constant): Recombinant therapeutic protein targeting GHBP/GHIP |
| Biosimilar | GMP-Bios-INN-995 | Pre-Made Somatropin Biosimilar, Recombinant Protein targeting GHR: Recombinant therapeutic protein targeting GHBP/GHIP |
| Target Antigen | Products Developing | Multi-species GHR/ GHBP/ GHIP VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T02333 |
| Target Name | GHR |
| Gene ID | 2690,14600,25235,697986,403721,101093244,280805,100053020 |
| Gene Symbol and Synonyms | GHBP,GHIP,GHR,GHR/BP |
| Uniprot Accession | P10912,P16310,P79194,Q9TU69,O46600 |
| Uniprot Entry Name | GHR_HUMAN,GHR_MACMU,GHR_RAT,GHR_CANLF,GHR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000112964 |
| Target Classification | Kinase |
The target: GHR, gene name: GHR, also named as GHBP, GHIP. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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