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Anti-SO1B3/ SLCO1B3/ HBLRR monoclonal antibody
Anti-SO1B3/ SLCO1B3/ HBLRR antibody for FACS & in-vivo assay
Go to SLCO1B3/SLCO1B3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T02565-Ab-1/ GM-Tg-hg-T02565-Ab-2 | Anti-Human SLCO1B3 monoclonal antibody | Human |
| GM-Tg-rg-T02565-Ab-1/ GM-Tg-rg-T02565-Ab-2 | Anti-Rat SLCO1B3 monoclonal antibody | Rat |
| GM-Tg-mg-T02565-Ab-1/ GM-Tg-mg-T02565-Ab-2 | Anti-Mouse SLCO1B3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T02565-Ab-1/ GM-Tg-cynog-T02565-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLCO1B3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T02565-Ab-1/ GM-Tg-felg-T02565-Ab-2 | Anti-Feline SLCO1B3 monoclonal antibody | Feline |
| GM-Tg-cang-T02565-Ab-1/ GM-Tg-cang-T02565-Ab-2 | Anti-Canine SLCO1B3 monoclonal antibody | Canine |
| GM-Tg-bovg-T02565-Ab-1/ GM-Tg-bovg-T02565-Ab-2 | Anti-Bovine SLCO1B3 monoclonal antibody | Bovine |
| GM-Tg-equg-T02565-Ab-1/ GM-Tg-equg-T02565-Ab-2 | Anti-Equine SLCO1B3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T02565-Ab-1/ GM-Tg-hg-T02565-Ab-2; GM-Tg-rg-T02565-Ab-1/ GM-Tg-rg-T02565-Ab-2; GM-Tg-mg-T02565-Ab-1/ GM-Tg-mg-T02565-Ab-2; GM-Tg-cynog-T02565-Ab-1/ GM-Tg-cynog-T02565-Ab-2; GM-Tg-felg-T02565-Ab-1/ GM-Tg-felg-T02565-Ab-2; GM-Tg-cang-T02565-Ab-1/ GM-Tg-cang-T02565-Ab-2; GM-Tg-bovg-T02565-Ab-1/ GM-Tg-bovg-T02565-Ab-2; GM-Tg-equg-T02565-Ab-1/ GM-Tg-equg-T02565-Ab-2 |
| Products Name | Anti-SLCO1B3 monoclonal antibody |
| Format | mab |
| Target Name | SLCO1B3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLCO1B3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SO1B3/ SLCO1B3/ HBLRR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000089 | human SLCO1B3 Lentivirus particle |
| ORF Viral Vector | pGMLV000089 | human SLCO1B3 Lentivirus plasmid |
Target information
| Target ID | GM-T02565 |
| Target Name | SLCO1B3 |
| Gene ID | 28234,28253,58978,574354,100068155 |
| Gene Symbol and Synonyms | 7330442B20Rik,HBLRR,lst-1,LST-2,LST-3™13,LST3,mlst-1,OATP-4,OATP-8,OATP-C,Oatp1b2,OATP1B3,Oatp1b4,OATP2,Oatp4,OATP8,OATPC,rlst-1,Slc21a10,Slc21a6,SLC21A8,Slco1b2,SLCO1B3,Slco1b4 |
| Uniprot Accession | Q9NPD5,Q9QZX8 |
| Uniprot Entry Name | SO1B3_HUMAN,SO1B2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000111700 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SLCO1B3, gene name: SLCO1B3, also named as HBLRR, LST-2, LST-3™13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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