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Anti-IFNB/ IFNB1/ IFB functional antibody
Anti-IFNB/ IFNB1/ IFB functional antibody for cell culture, ELISA & in-vivo assay
Go to IFNB1/IFNB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T02808-Ab-1/ GM-Tg-hg-T02808-Ab-2 | Anti-Human IFNB1 monoclonal antibody | Human |
| GM-Tg-rg-T02808-Ab-1/ GM-Tg-rg-T02808-Ab-2 | Anti-Rat IFNB1 monoclonal antibody | Rat |
| GM-Tg-mg-T02808-Ab-1/ GM-Tg-mg-T02808-Ab-2 | Anti-Mouse IFNB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T02808-Ab-1/ GM-Tg-cynog-T02808-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IFNB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T02808-Ab-1/ GM-Tg-felg-T02808-Ab-2 | Anti-Feline IFNB1 monoclonal antibody | Feline |
| GM-Tg-cang-T02808-Ab-1/ GM-Tg-cang-T02808-Ab-2 | Anti-Canine IFNB1 monoclonal antibody | Canine |
| GM-Tg-bovg-T02808-Ab-1/ GM-Tg-bovg-T02808-Ab-2 | Anti-Bovine IFNB1 monoclonal antibody | Bovine |
| GM-Tg-equg-T02808-Ab-1/ GM-Tg-equg-T02808-Ab-2 | Anti-Equine IFNB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T02808-Ab-1/ GM-Tg-hg-T02808-Ab-2; GM-Tg-rg-T02808-Ab-1/ GM-Tg-rg-T02808-Ab-2; GM-Tg-mg-T02808-Ab-1/ GM-Tg-mg-T02808-Ab-2; GM-Tg-cynog-T02808-Ab-1/ GM-Tg-cynog-T02808-Ab-2; GM-Tg-felg-T02808-Ab-1/ GM-Tg-felg-T02808-Ab-2; GM-Tg-cang-T02808-Ab-1/ GM-Tg-cang-T02808-Ab-2; GM-Tg-bovg-T02808-Ab-1/ GM-Tg-bovg-T02808-Ab-2; GM-Tg-equg-T02808-Ab-1/ GM-Tg-equg-T02808-Ab-2 |
| Products Name | Anti-IFNB1 monoclonal antibody |
| Format | mab |
| Target Name | IFNB1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IFNB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T02808-Ag-1 | Recombinant multi-species IFNB/ IFNB1/ IFB protein |
| Cytokine | GM-Tg-g-T02808-Ag-1 | interferon, beta 1, fibroblast (IFNB1) protein |
| ORF Viral Vector | pGMAP000549 | Human IFNB1 Adenovirus plasmid |
| ORF Viral Vector | pGMLP000557 | human IFNB1 Lentivirus plasmid |
| ORF Viral Vector | vGMAP000549 | Human IFNB1 Adenovirus particle |
| ORF Viral Vector | vGMLP000557 | human IFNB1 Lentivirus particle |
| ORF Viral Vector | pGMLPm000109 | mouse Ifnb1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000109 | mouse Ifnb1 Lentivirus particle |
Target information
| Target ID | GM-T02808 |
| Target Name | IFNB1 |
| Gene ID | 3456,15977,24481,711414,481558,493849 |
| Gene Symbol and Synonyms | If1da1,IFB,IFF,IFN-beta,IFNB,IFNB1 |
| Uniprot Accession | P01574,P70499,Q9N2J0 |
| Uniprot Entry Name | IFNB_HUMAN,IFNB_RAT,IFNB_FELCA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000171855 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IFNB1, gene name: IFNB1, also named as IFB, IFF, IFN-beta, IFNB. This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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