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Anti-MMP12/ MMP-12/ HME functional antibody
Anti-MMP12/ MMP-12/ HME functional antibody for cell culture, ELISA & in-vivo assay
Go to MMP-12/MMP12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T03500-Ab-1/ GM-Tg-hg-T03500-Ab-2 | Anti-Human MMP-12/MMP12 monoclonal antibody | Human |
| GM-Tg-rg-T03500-Ab-1/ GM-Tg-rg-T03500-Ab-2 | Anti-Rat MMP-12/MMP12 monoclonal antibody | Rat |
| GM-Tg-mg-T03500-Ab-1/ GM-Tg-mg-T03500-Ab-2 | Anti-Mouse MMP-12/MMP12 monoclonal antibody | Mouse |
| GM-Tg-cynog-T03500-Ab-1/ GM-Tg-cynog-T03500-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MMP-12/MMP12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T03500-Ab-1/ GM-Tg-felg-T03500-Ab-2 | Anti-Feline MMP-12/MMP12 monoclonal antibody | Feline |
| GM-Tg-cang-T03500-Ab-1/ GM-Tg-cang-T03500-Ab-2 | Anti-Canine MMP-12/MMP12 monoclonal antibody | Canine |
| GM-Tg-bovg-T03500-Ab-1/ GM-Tg-bovg-T03500-Ab-2 | Anti-Bovine MMP-12/MMP12 monoclonal antibody | Bovine |
| GM-Tg-equg-T03500-Ab-1/ GM-Tg-equg-T03500-Ab-2 | Anti-Equine MMP-12/MMP12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T03500-Ab-1/ GM-Tg-hg-T03500-Ab-2; GM-Tg-rg-T03500-Ab-1/ GM-Tg-rg-T03500-Ab-2; GM-Tg-mg-T03500-Ab-1/ GM-Tg-mg-T03500-Ab-2; GM-Tg-cynog-T03500-Ab-1/ GM-Tg-cynog-T03500-Ab-2; GM-Tg-felg-T03500-Ab-1/ GM-Tg-felg-T03500-Ab-2; GM-Tg-cang-T03500-Ab-1/ GM-Tg-cang-T03500-Ab-2; GM-Tg-bovg-T03500-Ab-1/ GM-Tg-bovg-T03500-Ab-2; GM-Tg-equg-T03500-Ab-1/ GM-Tg-equg-T03500-Ab-2 |
| Products Name | Anti-MMP-12/MMP12 monoclonal antibody |
| Format | mab |
| Target Name | MMP-12 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MMP-12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T03500-Ag-1 | Recombinant multi-species MMP12/ MMP-12/ HME protein |
| ORF Viral Vector | pGMLP002965 | human MMP12 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002965 | human MMP12 Lentivirus particle |
| ORF Viral Vector | pGMLPm002027 | mouse Mmp12 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002027 | mouse Mmp12 Lentivirus particle |
Target information
| Target ID | GM-T03500 |
| Target Name | MMP-12 |
| Gene ID | 4321,17381,117033,703867,611789,101084472,526981,100069047 |
| Gene Symbol and Synonyms | HME,ME,MME,Mmel,MMP-12,MMP12 |
| Uniprot Accession | P39900,Q63341 |
| Uniprot Entry Name | MMP12_HUMAN,MMP12_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000262406 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: MMP-12, gene name: MMP12, also named as HME, ME, MME, MMP-12. This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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