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Anti-SDF1/ CXCL12/ IRH functional antibody
Anti-SDF1/ CXCL12/ IRH functional antibody for cell culture, ELISA & in-vivo assay
Go to CXCL12/CXCL12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T04773-Ab-1/ GM-Tg-hg-T04773-Ab-2 | Anti-Human CXCL12 monoclonal antibody | Human |
| GM-Tg-rg-T04773-Ab-1/ GM-Tg-rg-T04773-Ab-2 | Anti-Rat CXCL12 monoclonal antibody | Rat |
| GM-Tg-mg-T04773-Ab-1/ GM-Tg-mg-T04773-Ab-2 | Anti-Mouse CXCL12 monoclonal antibody | Mouse |
| GM-Tg-cynog-T04773-Ab-1/ GM-Tg-cynog-T04773-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CXCL12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T04773-Ab-1/ GM-Tg-felg-T04773-Ab-2 | Anti-Feline CXCL12 monoclonal antibody | Feline |
| GM-Tg-cang-T04773-Ab-1/ GM-Tg-cang-T04773-Ab-2 | Anti-Canine CXCL12 monoclonal antibody | Canine |
| GM-Tg-bovg-T04773-Ab-1/ GM-Tg-bovg-T04773-Ab-2 | Anti-Bovine CXCL12 monoclonal antibody | Bovine |
| GM-Tg-equg-T04773-Ab-1/ GM-Tg-equg-T04773-Ab-2 | Anti-Equine CXCL12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T04773-Ab-1/ GM-Tg-hg-T04773-Ab-2; GM-Tg-rg-T04773-Ab-1/ GM-Tg-rg-T04773-Ab-2; GM-Tg-mg-T04773-Ab-1/ GM-Tg-mg-T04773-Ab-2; GM-Tg-cynog-T04773-Ab-1/ GM-Tg-cynog-T04773-Ab-2; GM-Tg-felg-T04773-Ab-1/ GM-Tg-felg-T04773-Ab-2; GM-Tg-cang-T04773-Ab-1/ GM-Tg-cang-T04773-Ab-2; GM-Tg-bovg-T04773-Ab-1/ GM-Tg-bovg-T04773-Ab-2; GM-Tg-equg-T04773-Ab-1/ GM-Tg-equg-T04773-Ab-2 |
| Products Name | Anti-CXCL12 monoclonal antibody |
| Format | mab |
| Target Name | CXCL12 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CXCL12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T04773 |
| Target Name | CXCL12 |
| Gene ID | 6387,20315,24772,574334,449622,493806,613811,100049872 |
| Gene Symbol and Synonyms | CXCL12,IRH,PBSF,SCYB12,SDF-1,SDF1,TLSF,TPAR1 |
| Uniprot Accession | P48061,O62657 |
| Uniprot Entry Name | SDF1_HUMAN,SDF1_FELCA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000107562 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: CXCL12, gene name: CXCL12, also named as IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1. This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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