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Anti-IRS2 monoclonal antibody
Pre-made anti-IRS2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to IRS2/IRS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T06128-Ab-1/ GM-Tg-hg-T06128-Ab-2 | Anti-Human IRS2 monoclonal antibody | Human |
| GM-Tg-rg-T06128-Ab-1/ GM-Tg-rg-T06128-Ab-2 | Anti-Rat IRS2 monoclonal antibody | Rat |
| GM-Tg-mg-T06128-Ab-1/ GM-Tg-mg-T06128-Ab-2 | Anti-Mouse IRS2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T06128-Ab-1/ GM-Tg-cynog-T06128-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IRS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T06128-Ab-1/ GM-Tg-felg-T06128-Ab-2 | Anti-Feline IRS2 monoclonal antibody | Feline |
| GM-Tg-cang-T06128-Ab-1/ GM-Tg-cang-T06128-Ab-2 | Anti-Canine IRS2 monoclonal antibody | Canine |
| GM-Tg-bovg-T06128-Ab-1/ GM-Tg-bovg-T06128-Ab-2 | Anti-Bovine IRS2 monoclonal antibody | Bovine |
| GM-Tg-equg-T06128-Ab-1/ GM-Tg-equg-T06128-Ab-2 | Anti-Equine IRS2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T06128-Ab-1/ GM-Tg-hg-T06128-Ab-2; GM-Tg-rg-T06128-Ab-1/ GM-Tg-rg-T06128-Ab-2; GM-Tg-mg-T06128-Ab-1/ GM-Tg-mg-T06128-Ab-2; GM-Tg-cynog-T06128-Ab-1/ GM-Tg-cynog-T06128-Ab-2; GM-Tg-felg-T06128-Ab-1/ GM-Tg-felg-T06128-Ab-2; GM-Tg-cang-T06128-Ab-1/ GM-Tg-cang-T06128-Ab-2; GM-Tg-bovg-T06128-Ab-1/ GM-Tg-bovg-T06128-Ab-2; GM-Tg-equg-T06128-Ab-1/ GM-Tg-equg-T06128-Ab-2 |
| Products Name | Anti-IRS2 monoclonal antibody |
| Format | mab |
| Target Name | IRS2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-IRS2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T06128-Ag-1 | Recombinant multi-species IRS2/ IRS-2 protein |
Target information
| Target ID | GM-T06128 |
| Target Name | IRS2 |
| Gene ID | 8660,384783,29376,698536,485548,101095791,100300012,100146249 |
| Gene Symbol and Synonyms | 4PS,IRS-2,IRS2 |
| Uniprot Accession | Q9Y4H2 |
| Uniprot Entry Name | IRS2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000185950 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: IRS2, gene name: IRS2, also named as IRS-2. This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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