Anti-ACTHR/ MC2R monoclonal antibody

Anti-ACTHR/ MC2R antibody for FACS & in-vivo assay

Target products collectionGo to MC2R/MC2R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T08898-Ab-1/ GM-Tg-hg-T08898-Ab-2Anti-Human MC2R monoclonal antibodyHuman
GM-Tg-rg-T08898-Ab-1/ GM-Tg-rg-T08898-Ab-2Anti-Rat MC2R monoclonal antibodyRat
GM-Tg-mg-T08898-Ab-1/ GM-Tg-mg-T08898-Ab-2Anti-Mouse MC2R monoclonal antibodyMouse
GM-Tg-cynog-T08898-Ab-1/ GM-Tg-cynog-T08898-Ab-2Anti-Cynomolgus/ Rhesus macaque MC2R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T08898-Ab-1/ GM-Tg-felg-T08898-Ab-2Anti-Feline MC2R monoclonal antibodyFeline
GM-Tg-cang-T08898-Ab-1/ GM-Tg-cang-T08898-Ab-2Anti-Canine MC2R monoclonal antibodyCanine
GM-Tg-bovg-T08898-Ab-1/ GM-Tg-bovg-T08898-Ab-2Anti-Bovine MC2R monoclonal antibodyBovine
GM-Tg-equg-T08898-Ab-1/ GM-Tg-equg-T08898-Ab-2Anti-Equine MC2R monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T08898-Ab-1/ GM-Tg-hg-T08898-Ab-2; GM-Tg-rg-T08898-Ab-1/ GM-Tg-rg-T08898-Ab-2;
GM-Tg-mg-T08898-Ab-1/ GM-Tg-mg-T08898-Ab-2; GM-Tg-cynog-T08898-Ab-1/ GM-Tg-cynog-T08898-Ab-2;
GM-Tg-felg-T08898-Ab-1/ GM-Tg-felg-T08898-Ab-2; GM-Tg-cang-T08898-Ab-1/ GM-Tg-cang-T08898-Ab-2;
GM-Tg-bovg-T08898-Ab-1/ GM-Tg-bovg-T08898-Ab-2; GM-Tg-equg-T08898-Ab-1/ GM-Tg-equg-T08898-Ab-2
Products NameAnti-MC2R monoclonal antibody
Formatmab
Target NameMC2R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MC2R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ACTHR/ MC2R VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T08898
    Target NameMC2R
    Gene ID4158,17200,282839,114673757,100855756,692350,281299,100057018
    Gene Symbol and SynonymsACTH-R,ACTHR,MC2-R,MC2R
    Uniprot AccessionQ01718,P34974
    Uniprot Entry NameACTHR_HUMAN,ACTHR_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000185231
    Target ClassificationTumor-associated antigen (TAA)

    The target: MC2R, gene name: MC2R, also named as ACTHR. MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.