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Anti-GBRG2/ GABRG2/ CAE2 monoclonal antibody
Anti-GBRG2/ GABRG2/ CAE2 antibody for FACS & in-vivo assay
Go to GABRG2/GABRG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T08910-Ab-1/ GM-Tg-hg-T08910-Ab-2 | Anti-Human GABRG2 monoclonal antibody | Human |
| GM-Tg-rg-T08910-Ab-1/ GM-Tg-rg-T08910-Ab-2 | Anti-Rat GABRG2 monoclonal antibody | Rat |
| GM-Tg-mg-T08910-Ab-1/ GM-Tg-mg-T08910-Ab-2 | Anti-Mouse GABRG2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T08910-Ab-1/ GM-Tg-cynog-T08910-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GABRG2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T08910-Ab-1/ GM-Tg-felg-T08910-Ab-2 | Anti-Feline GABRG2 monoclonal antibody | Feline |
| GM-Tg-cang-T08910-Ab-1/ GM-Tg-cang-T08910-Ab-2 | Anti-Canine GABRG2 monoclonal antibody | Canine |
| GM-Tg-bovg-T08910-Ab-1/ GM-Tg-bovg-T08910-Ab-2 | Anti-Bovine GABRG2 monoclonal antibody | Bovine |
| GM-Tg-equg-T08910-Ab-1/ GM-Tg-equg-T08910-Ab-2 | Anti-Equine GABRG2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T08910-Ab-1/ GM-Tg-hg-T08910-Ab-2; GM-Tg-rg-T08910-Ab-1/ GM-Tg-rg-T08910-Ab-2; GM-Tg-mg-T08910-Ab-1/ GM-Tg-mg-T08910-Ab-2; GM-Tg-cynog-T08910-Ab-1/ GM-Tg-cynog-T08910-Ab-2; GM-Tg-felg-T08910-Ab-1/ GM-Tg-felg-T08910-Ab-2; GM-Tg-cang-T08910-Ab-1/ GM-Tg-cang-T08910-Ab-2; GM-Tg-bovg-T08910-Ab-1/ GM-Tg-bovg-T08910-Ab-2; GM-Tg-equg-T08910-Ab-1/ GM-Tg-equg-T08910-Ab-2 |
| Products Name | Anti-GABRG2 monoclonal antibody |
| Format | mab |
| Target Name | GABRG2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GABRG2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GBRG2/ GABRG2/ CAE2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm002486 | mouse Gabrg2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002486 | mouse Gabrg2 Lentivirus particle |
Target information
| Target ID | GM-T08910 |
| Target Name | GABRG2 |
| Gene ID | 2566,14406,29709,697248,489141,100286791,282240,100059571 |
| Gene Symbol and Synonyms | CAE2,DEE74,ECA2,EIEE74,FEB8,GABAA-R,Gabrg-2,GABRG2,gamma2,GEFSP3 |
| Uniprot Accession | P18507,P18508,P22300 |
| Uniprot Entry Name | GBRG2_HUMAN,GBRG2_RAT,GBRG2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000113327 |
| Target Classification | N/A |
The target: GABRG2, gene name: GABRG2, also named as CAE2, ECA2, GEFSP3. This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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