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Anti-CXCR5/ BLR1/ CD185 monoclonal antibody
Anti-CXCR5/ BLR1/ CD185 antibody for FACS & in-vivo assay
Go to CXCR5/CXCR5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T09528-Ab-1/ GM-Tg-hg-T09528-Ab-2 | Anti-Human CXCR5 monoclonal antibody | Human |
| GM-Tg-rg-T09528-Ab-1/ GM-Tg-rg-T09528-Ab-2 | Anti-Rat CXCR5 monoclonal antibody | Rat |
| GM-Tg-mg-T09528-Ab-1/ GM-Tg-mg-T09528-Ab-2 | Anti-Mouse CXCR5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T09528-Ab-1/ GM-Tg-cynog-T09528-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CXCR5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T09528-Ab-1/ GM-Tg-felg-T09528-Ab-2 | Anti-Feline CXCR5 monoclonal antibody | Feline |
| GM-Tg-cang-T09528-Ab-1/ GM-Tg-cang-T09528-Ab-2 | Anti-Canine CXCR5 monoclonal antibody | Canine |
| GM-Tg-bovg-T09528-Ab-1/ GM-Tg-bovg-T09528-Ab-2 | Anti-Bovine CXCR5 monoclonal antibody | Bovine |
| GM-Tg-equg-T09528-Ab-1/ GM-Tg-equg-T09528-Ab-2 | Anti-Equine CXCR5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T09528-Ab-1/ GM-Tg-hg-T09528-Ab-2; GM-Tg-rg-T09528-Ab-1/ GM-Tg-rg-T09528-Ab-2; GM-Tg-mg-T09528-Ab-1/ GM-Tg-mg-T09528-Ab-2; GM-Tg-cynog-T09528-Ab-1/ GM-Tg-cynog-T09528-Ab-2; GM-Tg-felg-T09528-Ab-1/ GM-Tg-felg-T09528-Ab-2; GM-Tg-cang-T09528-Ab-1/ GM-Tg-cang-T09528-Ab-2; GM-Tg-bovg-T09528-Ab-1/ GM-Tg-bovg-T09528-Ab-2; GM-Tg-equg-T09528-Ab-1/ GM-Tg-equg-T09528-Ab-2 |
| Products Name | Anti-CXCR5 monoclonal antibody |
| Format | mab |
| Target Name | CXCR5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CXCR5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CXCR5/ BLR1/ CD185 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T09528-Ag-1 | chemokine (C-X-C motif) receptor 5 (CXCR5) protein |
| ORF Viral Vector | pGMLP003601 | human CXCR5 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003601 | human CXCR5 Lentivirus particle |
Target information
| Target ID | GM-T09528 |
| Target Name | CXCR5 |
| Gene ID | 643,12145,29363,701792,489378,101092459,497021 |
| Gene Symbol and Synonyms | BLR1,CD185,CXC-R5,CXCR-5,CXCR5,Gpcr6,MDR15,NLR |
| Uniprot Accession | P32302,P34997 |
| Uniprot Entry Name | CXCR5_HUMAN,CXCR5_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000160683 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR |
The target: CXCR5, gene name: CXCR5, also named as BLR1, CD185, MDR15. This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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