- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-CATK/ CTSK/ CTS02 functional antibody
Anti-CATK/ CTSK/ CTS02 functional antibody for cell culture, ELISA & in-vivo assay
Go to CTSK/CTSK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T11388-Ab-1/ GM-Tg-hg-T11388-Ab-2 | Anti-Human CTSK monoclonal antibody | Human |
| GM-Tg-rg-T11388-Ab-1/ GM-Tg-rg-T11388-Ab-2 | Anti-Rat CTSK monoclonal antibody | Rat |
| GM-Tg-mg-T11388-Ab-1/ GM-Tg-mg-T11388-Ab-2 | Anti-Mouse CTSK monoclonal antibody | Mouse |
| GM-Tg-cynog-T11388-Ab-1/ GM-Tg-cynog-T11388-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CTSK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T11388-Ab-1/ GM-Tg-felg-T11388-Ab-2 | Anti-Feline CTSK monoclonal antibody | Feline |
| GM-Tg-cang-T11388-Ab-1/ GM-Tg-cang-T11388-Ab-2 | Anti-Canine CTSK monoclonal antibody | Canine |
| GM-Tg-bovg-T11388-Ab-1/ GM-Tg-bovg-T11388-Ab-2 | Anti-Bovine CTSK monoclonal antibody | Bovine |
| GM-Tg-equg-T11388-Ab-1/ GM-Tg-equg-T11388-Ab-2 | Anti-Equine CTSK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T11388-Ab-1/ GM-Tg-hg-T11388-Ab-2; GM-Tg-rg-T11388-Ab-1/ GM-Tg-rg-T11388-Ab-2; GM-Tg-mg-T11388-Ab-1/ GM-Tg-mg-T11388-Ab-2; GM-Tg-cynog-T11388-Ab-1/ GM-Tg-cynog-T11388-Ab-2; GM-Tg-felg-T11388-Ab-1/ GM-Tg-felg-T11388-Ab-2; GM-Tg-cang-T11388-Ab-1/ GM-Tg-cang-T11388-Ab-2; GM-Tg-bovg-T11388-Ab-1/ GM-Tg-bovg-T11388-Ab-2; GM-Tg-equg-T11388-Ab-1/ GM-Tg-equg-T11388-Ab-2 |
| Products Name | Anti-CTSK monoclonal antibody |
| Format | mab |
| Target Name | CTSK |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CTSK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T11388-Ag-1 | Recombinant multi-species CATK/ CTSK/ CTS02 protein |
| ORF Viral Vector | vGMLP002924 | human CTSK Lentivirus particle |
| ORF Viral Vector | pGMLP002924 | human CTSK Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001954 | mouse Ctsk Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001954 | mouse Ctsk Lentivirus particle |
Target information
| Target ID | GM-T11388 |
| Target Name | CTSK |
| Gene ID | 1513,13038,29175,574112,608843,101093379,513038,100054991 |
| Gene Symbol and Synonyms | catK,CTS02,CTSK,CTSO,CTSO1,CTSO2,MMS10-Q,Ms10q,PKND,PYCD |
| Uniprot Accession | P43235,O35186,P61277,Q3ZKN1,Q5E968 |
| Uniprot Entry Name | CATK_HUMAN,CATK_MACMU,CATK_RAT,CATK_CANLF,CATK_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000143387 |
| Target Classification | N/A |
The target: CTSK, gene name: CTSK, also named as CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD. The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
