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Anti-DMD monoclonal antibody
Pre-made anti-DMD monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DMD/DMD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T12909-Ab-1/ GM-Tg-hg-T12909-Ab-2 | Anti-Human DMD monoclonal antibody | Human |
| GM-Tg-rg-T12909-Ab-1/ GM-Tg-rg-T12909-Ab-2 | Anti-Rat DMD monoclonal antibody | Rat |
| GM-Tg-mg-T12909-Ab-1/ GM-Tg-mg-T12909-Ab-2 | Anti-Mouse DMD monoclonal antibody | Mouse |
| GM-Tg-cynog-T12909-Ab-1/ GM-Tg-cynog-T12909-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DMD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T12909-Ab-1/ GM-Tg-felg-T12909-Ab-2 | Anti-Feline DMD monoclonal antibody | Feline |
| GM-Tg-cang-T12909-Ab-1/ GM-Tg-cang-T12909-Ab-2 | Anti-Canine DMD monoclonal antibody | Canine |
| GM-Tg-bovg-T12909-Ab-1/ GM-Tg-bovg-T12909-Ab-2 | Anti-Bovine DMD monoclonal antibody | Bovine |
| GM-Tg-equg-T12909-Ab-1/ GM-Tg-equg-T12909-Ab-2 | Anti-Equine DMD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T12909-Ab-1/ GM-Tg-hg-T12909-Ab-2; GM-Tg-rg-T12909-Ab-1/ GM-Tg-rg-T12909-Ab-2; GM-Tg-mg-T12909-Ab-1/ GM-Tg-mg-T12909-Ab-2; GM-Tg-cynog-T12909-Ab-1/ GM-Tg-cynog-T12909-Ab-2; GM-Tg-felg-T12909-Ab-1/ GM-Tg-felg-T12909-Ab-2; GM-Tg-cang-T12909-Ab-1/ GM-Tg-cang-T12909-Ab-2; GM-Tg-bovg-T12909-Ab-1/ GM-Tg-bovg-T12909-Ab-2; GM-Tg-equg-T12909-Ab-1/ GM-Tg-equg-T12909-Ab-2 |
| Products Name | Anti-DMD monoclonal antibody |
| Format | mab |
| Target Name | DMD |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DMD monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T12909-Ag-1 | Recombinant multi-species DMD/ BMD/ CMD3B protein |
Target information
| Target ID | GM-T12909 |
| Target Name | DMD |
| Gene ID | 1756,13405,24907,708073,606758,101084937,537655,100051515 |
| Gene Symbol and Synonyms | BMD,CMD3B,DMD,DNADMD1,Dp427,Dp71,DXS142,DXS164,DXS206,DXS230,DXS239,DXS268,DXS269,DXS270,DXS272,DXSmh7,DXSmh9,dys,mdx,MRX85,pke |
| Uniprot Accession | P11532,P11530,O97592 |
| Uniprot Entry Name | DMD_HUMAN,DMD_RAT,DMD_CANLF |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000198947 |
| Target Classification | N/A |
The target: DMD, gene name: DMD, also named as BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85. This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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