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Anti-WNT5A/ hWNT5A monoclonal antibody
Anti-WNT5A/ hWNT5A antibody for FACS & in-vivo assay
Go to WNT5A/WNT5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T13175-Ab-1/ GM-Tg-hg-T13175-Ab-2 | Anti-Human WNT5A monoclonal antibody | Human |
| GM-Tg-rg-T13175-Ab-1/ GM-Tg-rg-T13175-Ab-2 | Anti-Rat WNT5A monoclonal antibody | Rat |
| GM-Tg-mg-T13175-Ab-1/ GM-Tg-mg-T13175-Ab-2 | Anti-Mouse WNT5A monoclonal antibody | Mouse |
| GM-Tg-cynog-T13175-Ab-1/ GM-Tg-cynog-T13175-Ab-2 | Anti-Cynomolgus/ Rhesus macaque WNT5A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T13175-Ab-1/ GM-Tg-felg-T13175-Ab-2 | Anti-Feline WNT5A monoclonal antibody | Feline |
| GM-Tg-cang-T13175-Ab-1/ GM-Tg-cang-T13175-Ab-2 | Anti-Canine WNT5A monoclonal antibody | Canine |
| GM-Tg-bovg-T13175-Ab-1/ GM-Tg-bovg-T13175-Ab-2 | Anti-Bovine WNT5A monoclonal antibody | Bovine |
| GM-Tg-equg-T13175-Ab-1/ GM-Tg-equg-T13175-Ab-2 | Anti-Equine WNT5A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T13175-Ab-1/ GM-Tg-hg-T13175-Ab-2; GM-Tg-rg-T13175-Ab-1/ GM-Tg-rg-T13175-Ab-2; GM-Tg-mg-T13175-Ab-1/ GM-Tg-mg-T13175-Ab-2; GM-Tg-cynog-T13175-Ab-1/ GM-Tg-cynog-T13175-Ab-2; GM-Tg-felg-T13175-Ab-1/ GM-Tg-felg-T13175-Ab-2; GM-Tg-cang-T13175-Ab-1/ GM-Tg-cang-T13175-Ab-2; GM-Tg-bovg-T13175-Ab-1/ GM-Tg-bovg-T13175-Ab-2; GM-Tg-equg-T13175-Ab-1/ GM-Tg-equg-T13175-Ab-2 |
| Products Name | Anti-WNT5A monoclonal antibody |
| Format | mab |
| Target Name | WNT5A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-WNT5A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species WNT5A/ hWNT5A VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T13175-Ag-1 | wingless-type MMTV integration site family, member 5A (WNT5A) protein |
| ORF Viral Vector | pGMAP000537 | Human WNT5A Adenovirus plasmid |
| ORF Viral Vector | vGMAP000537 | Human WNT5A Adenovirus particle |
| ORF Viral Vector | pGMLP003836 | human WNT5A Lentivirus plasmid |
| ORF Viral Vector | vGMLP003836 | human WNT5A Lentivirus particle |
| ORF Viral Vector | pGMLPm002933 | mouse Wnt5a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002933 | mouse Wnt5a Lentivirus particle |
Target information
| Target ID | GM-T13175 |
| Target Name | WNT5A |
| Gene ID | 7474,22418,64566,705692,484721,101080694,530005,100059157 |
| Gene Symbol and Synonyms | 8030457G12Rik,hWNT5A,Wnt-5a,WNT5A |
| Uniprot Accession | P41221,Q9QXQ7 |
| Uniprot Entry Name | WNT5A_HUMAN,WNT5A_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000114251 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: WNT5A, gene name: WNT5A, also named as hWNT5A. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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