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Anti-LGR5/ FEX/ GPR49 monoclonal antibody
Anti-LGR5/ FEX/ GPR49 antibody for FACS & in-vivo assay
Go to LGR5/LGR5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T14231-Ab-1/ GM-Tg-hg-T14231-Ab-2 | Anti-Human LGR5 monoclonal antibody | Human |
| GM-Tg-rg-T14231-Ab-1/ GM-Tg-rg-T14231-Ab-2 | Anti-Rat LGR5 monoclonal antibody | Rat |
| GM-Tg-mg-T14231-Ab-1/ GM-Tg-mg-T14231-Ab-2 | Anti-Mouse LGR5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T14231-Ab-1/ GM-Tg-cynog-T14231-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LGR5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T14231-Ab-1/ GM-Tg-felg-T14231-Ab-2 | Anti-Feline LGR5 monoclonal antibody | Feline |
| GM-Tg-cang-T14231-Ab-1/ GM-Tg-cang-T14231-Ab-2 | Anti-Canine LGR5 monoclonal antibody | Canine |
| GM-Tg-bovg-T14231-Ab-1/ GM-Tg-bovg-T14231-Ab-2 | Anti-Bovine LGR5 monoclonal antibody | Bovine |
| GM-Tg-equg-T14231-Ab-1/ GM-Tg-equg-T14231-Ab-2 | Anti-Equine LGR5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T14231-Ab-1/ GM-Tg-hg-T14231-Ab-2; GM-Tg-rg-T14231-Ab-1/ GM-Tg-rg-T14231-Ab-2; GM-Tg-mg-T14231-Ab-1/ GM-Tg-mg-T14231-Ab-2; GM-Tg-cynog-T14231-Ab-1/ GM-Tg-cynog-T14231-Ab-2; GM-Tg-felg-T14231-Ab-1/ GM-Tg-felg-T14231-Ab-2; GM-Tg-cang-T14231-Ab-1/ GM-Tg-cang-T14231-Ab-2; GM-Tg-bovg-T14231-Ab-1/ GM-Tg-bovg-T14231-Ab-2; GM-Tg-equg-T14231-Ab-1/ GM-Tg-equg-T14231-Ab-2 |
| Products Name | Anti-LGR5 monoclonal antibody |
| Format | mab |
| Target Name | LGR5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LGR5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-440 | Pre-Made Petosemtamab biosimilar, Bispecific mAb, Anti-EGFR;LGR5 Antibody: Anti-ERBB/ERRP/HER1/mENA/ERBB1/PIG61/NISBD2;FEX/GPR49/GPR67/GRP49/HG38 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species LGR5/ FEX/ GPR49 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAD000158 | human LGR5 Adenovirus particle |
| ORF Viral Vector | pGMAD000158 | human LGR5 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm004327 | mouse Lgr5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004327 | mouse Lgr5 Lentivirus particle |
Target information
| Target ID | GM-T14231 |
| Target Name | LGR5 |
| Gene ID | 8549,14160,299802,718661,609478,101080720,520189,100064565 |
| Gene Symbol and Synonyms | FEX,GPR49,GPR67,GRP49,HG38,LGR5 |
| Uniprot Accession | O75473,D4AC13,F1MT22 |
| Uniprot Entry Name | LGR5_HUMAN,LGR5_RAT,LGR5_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000139292 |
| Target Classification | GPCR, Tumor-associated antigen (TAA) |
The target: LGR5, gene name: LGR5, also named as FEX, GPR49, GPR67, GRP49, HG38. The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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