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Anti-I10R2/ IL10RB/ CDW210B monoclonal antibody
Anti-I10R2/ IL10RB/ CDW210B antibody for FACS & in-vivo assay
Go to IL10RB/IL10RB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T14557-Ab-1/ GM-Tg-hg-T14557-Ab-2 | Anti-Human IL10RB monoclonal antibody | Human |
| GM-Tg-rg-T14557-Ab-1/ GM-Tg-rg-T14557-Ab-2 | Anti-Rat IL10RB monoclonal antibody | Rat |
| GM-Tg-mg-T14557-Ab-1/ GM-Tg-mg-T14557-Ab-2 | Anti-Mouse IL10RB monoclonal antibody | Mouse |
| GM-Tg-cynog-T14557-Ab-1/ GM-Tg-cynog-T14557-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL10RB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T14557-Ab-1/ GM-Tg-felg-T14557-Ab-2 | Anti-Feline IL10RB monoclonal antibody | Feline |
| GM-Tg-cang-T14557-Ab-1/ GM-Tg-cang-T14557-Ab-2 | Anti-Canine IL10RB monoclonal antibody | Canine |
| GM-Tg-bovg-T14557-Ab-1/ GM-Tg-bovg-T14557-Ab-2 | Anti-Bovine IL10RB monoclonal antibody | Bovine |
| GM-Tg-equg-T14557-Ab-1/ GM-Tg-equg-T14557-Ab-2 | Anti-Equine IL10RB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T14557-Ab-1/ GM-Tg-hg-T14557-Ab-2; GM-Tg-rg-T14557-Ab-1/ GM-Tg-rg-T14557-Ab-2; GM-Tg-mg-T14557-Ab-1/ GM-Tg-mg-T14557-Ab-2; GM-Tg-cynog-T14557-Ab-1/ GM-Tg-cynog-T14557-Ab-2; GM-Tg-felg-T14557-Ab-1/ GM-Tg-felg-T14557-Ab-2; GM-Tg-cang-T14557-Ab-1/ GM-Tg-cang-T14557-Ab-2; GM-Tg-bovg-T14557-Ab-1/ GM-Tg-bovg-T14557-Ab-2; GM-Tg-equg-T14557-Ab-1/ GM-Tg-equg-T14557-Ab-2 |
| Products Name | Anti-IL10RB monoclonal antibody |
| Format | mab |
| Target Name | IL10RB |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL10RB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-819 | Pre-Made Eflepedocokin Alfa Biosimilar, Fusion Protein targeting IL10RB fused with human IGHG2 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting CDW210B/CRF2-4/CRFB4/D21S58/D21S66/IL-10R2 |
| Target Antigen | Products Developing | Multi-species I10R2/ IL10RB/ CDW210B VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T14557-Ag-1 | interleukin 10 receptor, beta (IL10RB) protein |
| ORF Viral Vector | pGMLP004604 | human IL10RB Lentivirus plasmid |
| ORF Viral Vector | vGMLP004604 | human IL10RB Lentivirus particle |
| ORF Viral Vector | pGMLPm002089 | mouse Il10rb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002089 | mouse Il10rb Lentivirus particle |
Target information
| Target ID | GM-T14557 |
| Target Name | IL10RB |
| Gene ID | 3588,16155,304091,706012,478404,101090038,767864,100052549 |
| Gene Symbol and Synonyms | 6620401D04Rik,CDW210B,CRF2-4,CRFB4,D16H21S58,D21S58,D21S58h,D21S66,IBD25,IL-10R2,IL-10RB,Il10r2,IL10RB,RGD1560373 |
| Uniprot Accession | Q08334 |
| Uniprot Entry Name | I10R2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000243646 |
| Target Classification | N/A |
The target: IL10RB, gene name: IL10RB, also named as CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2. The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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