Anti-CD40L/ CD40LG/ CD154 monoclonal antibody

Anti-CD40L/ CD40LG/ CD154 antibody for FACS & in-vivo assay

Target products collectionGo to CD40LG/CD40LG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T14755-Ab-1/ GM-Tg-hg-T14755-Ab-2Anti-Human CD40LG monoclonal antibodyHuman
GM-Tg-rg-T14755-Ab-1/ GM-Tg-rg-T14755-Ab-2Anti-Rat CD40LG monoclonal antibodyRat
GM-Tg-mg-T14755-Ab-1/ GM-Tg-mg-T14755-Ab-2Anti-Mouse CD40LG monoclonal antibodyMouse
GM-Tg-cynog-T14755-Ab-1/ GM-Tg-cynog-T14755-Ab-2Anti-Cynomolgus/ Rhesus macaque CD40LG monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T14755-Ab-1/ GM-Tg-felg-T14755-Ab-2Anti-Feline CD40LG monoclonal antibodyFeline
GM-Tg-cang-T14755-Ab-1/ GM-Tg-cang-T14755-Ab-2Anti-Canine CD40LG monoclonal antibodyCanine
GM-Tg-bovg-T14755-Ab-1/ GM-Tg-bovg-T14755-Ab-2Anti-Bovine CD40LG monoclonal antibodyBovine
GM-Tg-equg-T14755-Ab-1/ GM-Tg-equg-T14755-Ab-2Anti-Equine CD40LG monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T14755-Ab-1/ GM-Tg-hg-T14755-Ab-2; GM-Tg-rg-T14755-Ab-1/ GM-Tg-rg-T14755-Ab-2;
GM-Tg-mg-T14755-Ab-1/ GM-Tg-mg-T14755-Ab-2; GM-Tg-cynog-T14755-Ab-1/ GM-Tg-cynog-T14755-Ab-2;
GM-Tg-felg-T14755-Ab-1/ GM-Tg-felg-T14755-Ab-2; GM-Tg-cang-T14755-Ab-1/ GM-Tg-cang-T14755-Ab-2;
GM-Tg-bovg-T14755-Ab-1/ GM-Tg-bovg-T14755-Ab-2; GM-Tg-equg-T14755-Ab-1/ GM-Tg-equg-T14755-Ab-2
Products NameAnti-CD40LG monoclonal antibody
Formatmab
Target NameCD40LG
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD40LG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-132Pre-Made Dapirolizumab biosimilar, Fab, Anti-CD40LG Antibody: Anti-IGM/IMD3/TRAP/gp39/CD154/CD40L/HIGM1/T-BAM/TNFSF5/hCD40L therapeutic antibody
    BiosimilarGMP-Bios-ab-501Pre-Made Ruplizumab biosimilar, Whole mAb, Anti-CD40LG Antibody: Anti-IGM/IMD3/TRAP/gp39/CD154/CD40L/HIGM1/T-BAM/TNFSF5/hCD40L therapeutic antibody
    BiosimilarGMP-Bios-INN-1026Pre-Made Toralizumab Biosimilar, Whole Mab, Anti-Cd40Lg Antibody: Anti-CD154/CD40L/HIGM1/IGM/IMD3/T-BAM/TNFSF5/TRAP/gp39/hCD40L therapeutic antibody
    BiosimilarGMP-Bios-INN-798Pre-Made Dazodalibep Biosimilar, Fusion Protein targeting CD40LG fused with ALB (albumin, human serum albumin, HSA): Recombinant therapeutic protein targeting CD154/CD40L/HIGM1/IGM/IMD3/T-BAM/TNFSF5/TRAP/gp39/hCD40L
    BiosimilarGMP-Bios-ab-307Pre-Made Letolizumab biosimilar, Single Domain Variable Fragment;H, Anti-CD40LG Antibody: Anti-IGM/IMD3/TRAP/gp39/CD154/CD40L/HIGM1/T-BAM/TNFSF5/hCD40L therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CD40L/ CD40LG/ CD154 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T14755-Ag-1CD40 ligand (CD154) protein
    ORF Viral VectorvGMLV000459human CD40LG Lentivirus particle
    ORF Viral VectorpGMLV000459human CD40LG Lentivirus plasmid
    ORF Viral VectorvGMAP000295Human CD40LG Adenovirus particle
    ORF Viral VectorpGMAP000295Human CD40LG Adenovirus plasmid
    ORF Viral VectorpGMLPm000314mouse Cd40lg Lentivirus plasmid
    ORF Viral VectorvGMLPm000314mouse Cd40lg Lentivirus particle


    Target information

    Target IDGM-T14755
    Target NameCD40LG
    Gene ID959,21947,84349,574160,403468,493850,100054624
    Gene Symbol and SynonymsCD154,CD40-L,CD40L,CD40LG,gp39,hCD40L,HIGM1,IGM,IMD3,Ly-62,Ly62,T-BAM,TNFSF5,Tnlg8b,TRAP
    Uniprot AccessionP29965,Q9Z2V2,P63304,O97626,O97605
    Uniprot Entry NameCD40L_HUMAN,CD40L_MACMU,CD40L_RAT,CD40L_FELCA,CD40L_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000102245
    Target ClassificationCheckpoint-Immuno Oncology

    The target: CD40LG, gene name: CD40LG, also named as CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L. The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.