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Anti-CX3C1/ CX3CR1/ CCRL1 monoclonal antibody
Anti-CX3C1/ CX3CR1/ CCRL1 antibody for FACS & in-vivo assay
Go to CX3CR1/CX3CR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T15033-Ab-1/ GM-Tg-hg-T15033-Ab-2 | Anti-Human CX3CR1 monoclonal antibody | Human |
| GM-Tg-rg-T15033-Ab-1/ GM-Tg-rg-T15033-Ab-2 | Anti-Rat CX3CR1 monoclonal antibody | Rat |
| GM-Tg-mg-T15033-Ab-1/ GM-Tg-mg-T15033-Ab-2 | Anti-Mouse CX3CR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T15033-Ab-1/ GM-Tg-cynog-T15033-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CX3CR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T15033-Ab-1/ GM-Tg-felg-T15033-Ab-2 | Anti-Feline CX3CR1 monoclonal antibody | Feline |
| GM-Tg-cang-T15033-Ab-1/ GM-Tg-cang-T15033-Ab-2 | Anti-Canine CX3CR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T15033-Ab-1/ GM-Tg-bovg-T15033-Ab-2 | Anti-Bovine CX3CR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T15033-Ab-1/ GM-Tg-equg-T15033-Ab-2 | Anti-Equine CX3CR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T15033-Ab-1/ GM-Tg-hg-T15033-Ab-2; GM-Tg-rg-T15033-Ab-1/ GM-Tg-rg-T15033-Ab-2; GM-Tg-mg-T15033-Ab-1/ GM-Tg-mg-T15033-Ab-2; GM-Tg-cynog-T15033-Ab-1/ GM-Tg-cynog-T15033-Ab-2; GM-Tg-felg-T15033-Ab-1/ GM-Tg-felg-T15033-Ab-2; GM-Tg-cang-T15033-Ab-1/ GM-Tg-cang-T15033-Ab-2; GM-Tg-bovg-T15033-Ab-1/ GM-Tg-bovg-T15033-Ab-2; GM-Tg-equg-T15033-Ab-1/ GM-Tg-equg-T15033-Ab-2 |
| Products Name | Anti-CX3CR1 monoclonal antibody |
| Format | mab |
| Target Name | CX3CR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CX3CR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CX3C1/ CX3CR1/ CCRL1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T15033-Ag-1 | chemokine (C-X3-C motif) receptor 1 (CX3CR1) protein |
| ORF Viral Vector | vGMLP001885 | human CX3CR1 Lentivirus particle |
| ORF Viral Vector | pGMLP001885 | human CX3CR1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000873 | house mouse Cx3cr1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002013 | mouse Cx3cr1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000873 | house mouse Cx3cr1 Lentivirus particle |
| ORF Viral Vector | vGMLPm002013 | mouse Cx3cr1 Lentivirus particle |
Target information
| Target ID | GM-T15033 |
| Target Name | CX3CR1 |
| Gene ID | 1524,13051,171056,693926,485599,101099898,100124525,100068350 |
| Gene Symbol and Synonyms | CCRL1,CMKBRL1,CMKDR1,CX3CR1,GPR13,GPRV28,mCX3CR1,Rbs11,V28 |
| Uniprot Accession | P49238,P35411,A6QNL7 |
| Uniprot Entry Name | CX3C1_HUMAN,CX3C1_RAT,CX3C1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000168329 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR |
The target: CX3CR1, gene name: CX3CR1, also named as CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28. Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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