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Anti-NOS1/ IHPS1/ N-NOS monoclonal antibody
Anti-NOS1/ IHPS1/ N-NOS antibody for FACS & in-vivo assay
Go to NOS1/NOS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T16117-Ab-1/ GM-Tg-hg-T16117-Ab-2 | Anti-Human NOS1 monoclonal antibody | Human |
| GM-Tg-rg-T16117-Ab-1/ GM-Tg-rg-T16117-Ab-2 | Anti-Rat NOS1 monoclonal antibody | Rat |
| GM-Tg-mg-T16117-Ab-1/ GM-Tg-mg-T16117-Ab-2 | Anti-Mouse NOS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T16117-Ab-1/ GM-Tg-cynog-T16117-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NOS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T16117-Ab-1/ GM-Tg-felg-T16117-Ab-2 | Anti-Feline NOS1 monoclonal antibody | Feline |
| GM-Tg-cang-T16117-Ab-1/ GM-Tg-cang-T16117-Ab-2 | Anti-Canine NOS1 monoclonal antibody | Canine |
| GM-Tg-bovg-T16117-Ab-1/ GM-Tg-bovg-T16117-Ab-2 | Anti-Bovine NOS1 monoclonal antibody | Bovine |
| GM-Tg-equg-T16117-Ab-1/ GM-Tg-equg-T16117-Ab-2 | Anti-Equine NOS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T16117-Ab-1/ GM-Tg-hg-T16117-Ab-2; GM-Tg-rg-T16117-Ab-1/ GM-Tg-rg-T16117-Ab-2; GM-Tg-mg-T16117-Ab-1/ GM-Tg-mg-T16117-Ab-2; GM-Tg-cynog-T16117-Ab-1/ GM-Tg-cynog-T16117-Ab-2; GM-Tg-felg-T16117-Ab-1/ GM-Tg-felg-T16117-Ab-2; GM-Tg-cang-T16117-Ab-1/ GM-Tg-cang-T16117-Ab-2; GM-Tg-bovg-T16117-Ab-1/ GM-Tg-bovg-T16117-Ab-2; GM-Tg-equg-T16117-Ab-1/ GM-Tg-equg-T16117-Ab-2 |
| Products Name | Anti-NOS1 monoclonal antibody |
| Format | mab |
| Target Name | NOS1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NOS1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NOS1/ IHPS1/ N-NOS VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T16117 |
| Target Name | NOS1 |
| Gene ID | 4842,18125,24598,693781,477498,101100342,536132,100051079 |
| Gene Symbol and Synonyms | 2310005C01Rik,bNOS,IHPS1,N-NOS,NC-NOS,nNOS,NO,NOS,Nos-1,NOS-I,NOS1 |
| Uniprot Accession | P29475,P29476 |
| Uniprot Entry Name | NOS1_HUMAN,NOS1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000089250 |
| Target Classification | N/A |
The target: NOS1, gene name: NOS1, also named as IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS. The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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