- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-CAH12/ CA-XII/ CA12 monoclonal antibody
Anti-CAH12/ CA-XII/ CA12 antibody for FACS & in-vivo assay
Go to CA-XII/CA12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T16987-Ab-1/ GM-Tg-hg-T16987-Ab-2 | Anti-Human CA-XII/CA12 monoclonal antibody | Human |
| GM-Tg-rg-T16987-Ab-1/ GM-Tg-rg-T16987-Ab-2 | Anti-Rat CA-XII/CA12 monoclonal antibody | Rat |
| GM-Tg-mg-T16987-Ab-1/ GM-Tg-mg-T16987-Ab-2 | Anti-Mouse CA-XII/CA12 monoclonal antibody | Mouse |
| GM-Tg-cynog-T16987-Ab-1/ GM-Tg-cynog-T16987-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CA-XII/CA12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T16987-Ab-1/ GM-Tg-felg-T16987-Ab-2 | Anti-Feline CA-XII/CA12 monoclonal antibody | Feline |
| GM-Tg-cang-T16987-Ab-1/ GM-Tg-cang-T16987-Ab-2 | Anti-Canine CA-XII/CA12 monoclonal antibody | Canine |
| GM-Tg-bovg-T16987-Ab-1/ GM-Tg-bovg-T16987-Ab-2 | Anti-Bovine CA-XII/CA12 monoclonal antibody | Bovine |
| GM-Tg-equg-T16987-Ab-1/ GM-Tg-equg-T16987-Ab-2 | Anti-Equine CA-XII/CA12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T16987-Ab-1/ GM-Tg-hg-T16987-Ab-2; GM-Tg-rg-T16987-Ab-1/ GM-Tg-rg-T16987-Ab-2; GM-Tg-mg-T16987-Ab-1/ GM-Tg-mg-T16987-Ab-2; GM-Tg-cynog-T16987-Ab-1/ GM-Tg-cynog-T16987-Ab-2; GM-Tg-felg-T16987-Ab-1/ GM-Tg-felg-T16987-Ab-2; GM-Tg-cang-T16987-Ab-1/ GM-Tg-cang-T16987-Ab-2; GM-Tg-bovg-T16987-Ab-1/ GM-Tg-bovg-T16987-Ab-2; GM-Tg-equg-T16987-Ab-1/ GM-Tg-equg-T16987-Ab-2 |
| Products Name | Anti-CA-XII/CA12 monoclonal antibody |
| Format | mab |
| Target Name | CA-XII |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CA-XII benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CAH12/ CA-XII/ CA12 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003574 | human CA12 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003574 | human CA12 Lentivirus particle |
| ORF Viral Vector | pGMLPm001870 | mouse Car12 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001870 | mouse Car12 Lentivirus particle |
Target information
| Target ID | GM-T16987 |
| Target Name | CA-XII |
| Gene ID | 771,76459,363085,705838,478333,101090522,614323,100054028 |
| Gene Symbol and Synonyms | 2310047E01Rik,CA-XII,CA12,Car12,CAXII,HsT18816,T18816 |
| Uniprot Accession | O43570 |
| Uniprot Entry Name | CAH12_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000074410 |
| Target Classification | N/A |
The target: CA-XII, gene name: CA12, also named as CA-XII, CAXII, HsT18816, T18816. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
