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Anti-HTRA1/ ARMD7/ CADASIL2 monoclonal antibody
Anti-HTRA1/ ARMD7/ CADASIL2 antibody for FACS & in-vivo assay
Go to HTRA1/HTRA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T17642-Ab-1/ GM-Tg-hg-T17642-Ab-2 | Anti-Human HTRA1 monoclonal antibody | Human |
| GM-Tg-rg-T17642-Ab-1/ GM-Tg-rg-T17642-Ab-2 | Anti-Rat HTRA1 monoclonal antibody | Rat |
| GM-Tg-mg-T17642-Ab-1/ GM-Tg-mg-T17642-Ab-2 | Anti-Mouse HTRA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T17642-Ab-1/ GM-Tg-cynog-T17642-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HTRA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T17642-Ab-1/ GM-Tg-felg-T17642-Ab-2 | Anti-Feline HTRA1 monoclonal antibody | Feline |
| GM-Tg-cang-T17642-Ab-1/ GM-Tg-cang-T17642-Ab-2 | Anti-Canine HTRA1 monoclonal antibody | Canine |
| GM-Tg-bovg-T17642-Ab-1/ GM-Tg-bovg-T17642-Ab-2 | Anti-Bovine HTRA1 monoclonal antibody | Bovine |
| GM-Tg-equg-T17642-Ab-1/ GM-Tg-equg-T17642-Ab-2 | Anti-Equine HTRA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T17642-Ab-1/ GM-Tg-hg-T17642-Ab-2; GM-Tg-rg-T17642-Ab-1/ GM-Tg-rg-T17642-Ab-2; GM-Tg-mg-T17642-Ab-1/ GM-Tg-mg-T17642-Ab-2; GM-Tg-cynog-T17642-Ab-1/ GM-Tg-cynog-T17642-Ab-2; GM-Tg-felg-T17642-Ab-1/ GM-Tg-felg-T17642-Ab-2; GM-Tg-cang-T17642-Ab-1/ GM-Tg-cang-T17642-Ab-2; GM-Tg-bovg-T17642-Ab-1/ GM-Tg-bovg-T17642-Ab-2; GM-Tg-equg-T17642-Ab-1/ GM-Tg-equg-T17642-Ab-2 |
| Products Name | Anti-HTRA1 monoclonal antibody |
| Format | mab |
| Target Name | HTRA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HTRA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-668 | Pre-Made Galegenimab biosimilar, Whole mAb, Anti-HTRA1 Antibody: Anti-ARMD7/CADASIL2/CARASIL/HtrA/L56/ORF480/PRSS11 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species HTRA1/ ARMD7/ CADASIL2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAD000147 | human HTRA1 Adenovirus particle |
| ORF Viral Vector | pGMAD000147 | human HTRA1 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm004330 | mouse Htra1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004330 | mouse Htra1 Lentivirus particle |
Target information
| Target ID | GM-T17642 |
| Target Name | HTRA1 |
| Gene ID | 5654,56213,65164,705855,477852,101095920,282326,100064570 |
| Gene Symbol and Synonyms | ARMD7,CADASIL2,CARASIL,HtrA,HTRA1,L56,ORF480,PRSS11,RSPP11 |
| Uniprot Accession | Q92743,Q9QZK5,F1N152 |
| Uniprot Entry Name | HTRA1_HUMAN,HTRA1_RAT,HTRA1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | Ovary Cancer, small vessel disease (SVD) |
| Gene Ensembl | ENSG00000166033 |
| Target Classification | N/A |
The target: HTRA1, gene name: HTRA1, also named as ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11. This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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