Anti-MUC1/ ADMCKD/ ADMCKD1 monoclonal antibody
Anti-MUC1/ ADMCKD/ ADMCKD1 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T18779-Ab-1/ GM-Tg-hg-T18779-Ab-2 | Anti-Human MUC1 monoclonal antibody | Human |
GM-Tg-rg-T18779-Ab-1/ GM-Tg-rg-T18779-Ab-2 | Anti-Rat MUC1 monoclonal antibody | Rat |
GM-Tg-mg-T18779-Ab-1/ GM-Tg-mg-T18779-Ab-2 | Anti-Mouse MUC1 monoclonal antibody | Mouse |
GM-Tg-cynog-T18779-Ab-1/ GM-Tg-cynog-T18779-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MUC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T18779-Ab-1/ GM-Tg-felg-T18779-Ab-2 | Anti-Feline MUC1 monoclonal antibody | Feline |
GM-Tg-cang-T18779-Ab-1/ GM-Tg-cang-T18779-Ab-2 | Anti-Canine MUC1 monoclonal antibody | Canine |
GM-Tg-bovg-T18779-Ab-1/ GM-Tg-bovg-T18779-Ab-2 | Anti-Bovine MUC1 monoclonal antibody | Bovine |
GM-Tg-equg-T18779-Ab-1/ GM-Tg-equg-T18779-Ab-2 | Anti-Equine MUC1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T18779-Ab-1/ GM-Tg-hg-T18779-Ab-2; GM-Tg-rg-T18779-Ab-1/ GM-Tg-rg-T18779-Ab-2; GM-Tg-mg-T18779-Ab-1/ GM-Tg-mg-T18779-Ab-2; GM-Tg-cynog-T18779-Ab-1/ GM-Tg-cynog-T18779-Ab-2; GM-Tg-felg-T18779-Ab-1/ GM-Tg-felg-T18779-Ab-2; GM-Tg-cang-T18779-Ab-1/ GM-Tg-cang-T18779-Ab-2; GM-Tg-bovg-T18779-Ab-1/ GM-Tg-bovg-T18779-Ab-2; GM-Tg-equg-T18779-Ab-1/ GM-Tg-equg-T18779-Ab-2 |
Products Name | Anti-MUC1 monoclonal antibody |
Format | mab |
Target Name | MUC1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-MUC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
Target ID | GM-T18779 |
Target Name | MUC1 |
Gene ID | 4582,17829,24571,717546,448784,101093832,281333,100063415 |
Gene Symbol and Synonyms | ADMCKD,ADMCKD1,ADTKD2,CA 15-3,Ca15-3,CD227,EMA,H23AG,KL-6,MAM6,MCD,MCKD,MCKD1,MUC-1,MUC-1/SEC,MUC-1/X,MUC1,MUC1/ZD,mucin,PEM,PEMT,PUM |
Uniprot Accession | P15941,Q8WML4 |
Uniprot Entry Name | MUC1_HUMAN,MUC1_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | Ovary Cancer |
Gene Ensembl | ENSG00000185499 |
Target Classification | Checkpoint-Immuno Oncology |
The target: MUC1, gene name: MUC1, also named as ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X/ZD, PEM, PEMT, PUM, MUC1. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.