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Anti-PA2GA/ GIIA sPLA2/ PLA2G2A monoclonal antibody
Anti-PA2GA/ GIIA sPLA2/ PLA2G2A antibody for FACS & in-vivo assay
Go to GIIA sPLA2/PLA2G2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T19160-Ab-1/ GM-Tg-hg-T19160-Ab-2 | Anti-Human GIIA sPLA2/PLA2G2A monoclonal antibody | Human |
| GM-Tg-rg-T19160-Ab-1/ GM-Tg-rg-T19160-Ab-2 | Anti-Rat GIIA sPLA2/PLA2G2A monoclonal antibody | Rat |
| GM-Tg-mg-T19160-Ab-1/ GM-Tg-mg-T19160-Ab-2 | Anti-Mouse GIIA sPLA2/PLA2G2A monoclonal antibody | Mouse |
| GM-Tg-cynog-T19160-Ab-1/ GM-Tg-cynog-T19160-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GIIA sPLA2/PLA2G2A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T19160-Ab-1/ GM-Tg-felg-T19160-Ab-2 | Anti-Feline GIIA sPLA2/PLA2G2A monoclonal antibody | Feline |
| GM-Tg-cang-T19160-Ab-1/ GM-Tg-cang-T19160-Ab-2 | Anti-Canine GIIA sPLA2/PLA2G2A monoclonal antibody | Canine |
| GM-Tg-bovg-T19160-Ab-1/ GM-Tg-bovg-T19160-Ab-2 | Anti-Bovine GIIA sPLA2/PLA2G2A monoclonal antibody | Bovine |
| GM-Tg-equg-T19160-Ab-1/ GM-Tg-equg-T19160-Ab-2 | Anti-Equine GIIA sPLA2/PLA2G2A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T19160-Ab-1/ GM-Tg-hg-T19160-Ab-2; GM-Tg-rg-T19160-Ab-1/ GM-Tg-rg-T19160-Ab-2; GM-Tg-mg-T19160-Ab-1/ GM-Tg-mg-T19160-Ab-2; GM-Tg-cynog-T19160-Ab-1/ GM-Tg-cynog-T19160-Ab-2; GM-Tg-felg-T19160-Ab-1/ GM-Tg-felg-T19160-Ab-2; GM-Tg-cang-T19160-Ab-1/ GM-Tg-cang-T19160-Ab-2; GM-Tg-bovg-T19160-Ab-1/ GM-Tg-bovg-T19160-Ab-2; GM-Tg-equg-T19160-Ab-1/ GM-Tg-equg-T19160-Ab-2 |
| Products Name | Anti-GIIA sPLA2/PLA2G2A monoclonal antibody |
| Format | mab |
| Target Name | GIIA sPLA2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GIIA sPLA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PA2GA/ GIIA sPLA2/ PLA2G2A VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000318 | Human PLA2G2A Adenovirus particle |
| ORF Viral Vector | pGMAP000318 | Human PLA2G2A Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000153 | mouse Pla2g2a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000153 | mouse Pla2g2a Lentivirus particle |
Target information
| Target ID | GM-T19160 |
| Target Name | GIIA sPLA2 |
| Gene ID | 5320,18780,29692,704520,100037401 |
| Gene Symbol and Synonyms | EF,MOM1,PLA2,PLA2B,PLA2G2A,PLA2L,PLA2S,PLAS1,sPLA2,sPla2-IIA |
| Uniprot Accession | P14555,P14423 |
| Uniprot Entry Name | PA2GA_HUMAN,PA2GA_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000188257 |
| Target Classification | N/A |
The target: GIIA sPLA2, gene name: PLA2G2A, also named as MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2. The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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