Anti-PCFT/ SLC46A1/ G21 monoclonal antibody
Anti-PCFT/ SLC46A1/ G21 antibody for FACS & in-vivo assay
Go to SLC46A1/SLC46A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T19229-Ab-1/ GM-Tg-hg-T19229-Ab-2 | Anti-Human SLC46A1 monoclonal antibody | Human |
GM-Tg-rg-T19229-Ab-1/ GM-Tg-rg-T19229-Ab-2 | Anti-Rat SLC46A1 monoclonal antibody | Rat |
GM-Tg-mg-T19229-Ab-1/ GM-Tg-mg-T19229-Ab-2 | Anti-Mouse SLC46A1 monoclonal antibody | Mouse |
GM-Tg-cynog-T19229-Ab-1/ GM-Tg-cynog-T19229-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC46A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T19229-Ab-1/ GM-Tg-felg-T19229-Ab-2 | Anti-Feline SLC46A1 monoclonal antibody | Feline |
GM-Tg-cang-T19229-Ab-1/ GM-Tg-cang-T19229-Ab-2 | Anti-Canine SLC46A1 monoclonal antibody | Canine |
GM-Tg-bovg-T19229-Ab-1/ GM-Tg-bovg-T19229-Ab-2 | Anti-Bovine SLC46A1 monoclonal antibody | Bovine |
GM-Tg-equg-T19229-Ab-1/ GM-Tg-equg-T19229-Ab-2 | Anti-Equine SLC46A1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T19229-Ab-1/ GM-Tg-hg-T19229-Ab-2; GM-Tg-rg-T19229-Ab-1/ GM-Tg-rg-T19229-Ab-2; GM-Tg-mg-T19229-Ab-1/ GM-Tg-mg-T19229-Ab-2; GM-Tg-cynog-T19229-Ab-1/ GM-Tg-cynog-T19229-Ab-2; GM-Tg-felg-T19229-Ab-1/ GM-Tg-felg-T19229-Ab-2; GM-Tg-cang-T19229-Ab-1/ GM-Tg-cang-T19229-Ab-2; GM-Tg-bovg-T19229-Ab-1/ GM-Tg-bovg-T19229-Ab-2; GM-Tg-equg-T19229-Ab-1/ GM-Tg-equg-T19229-Ab-2 |
Products Name | Anti-SLC46A1 monoclonal antibody |
Format | mab |
Target Name | SLC46A1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-SLC46A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species PCFT/ SLC46A1/ G21 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLPm003784 | mouse Slc46a1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm003784 | mouse Slc46a1 Lentivirus particle |
Target information
Target ID | GM-T19229 |
Target Name | SLC46A1 |
Gene ID | 113235,52466,303333,708727,491166,101100096,511097,100072047 |
Gene Symbol and Synonyms | 1110002C08Rik,D11Ertd18e,G21,HCP1,hPCFT,HsPCFT,PCFT,RGD1309472,rPCFT,SLC46A1,TRPE |
Uniprot Accession | Q96NT5,Q5EBA8,Q05B81 |
Uniprot Entry Name | PCFT_HUMAN,PCFT_RAT,PCFT_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000076351 |
Target Classification | N/A |
The target: SLC46A1, gene name: SLC46A1, also named as G21, HCP1, PCFT. This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.