Anti-PCFT/ SLC46A1/ G21 monoclonal antibody

Anti-PCFT/ SLC46A1/ G21 antibody for FACS & in-vivo assay

Target products collectionGo to SLC46A1/SLC46A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T19229-Ab-1/ GM-Tg-hg-T19229-Ab-2Anti-Human SLC46A1 monoclonal antibodyHuman
GM-Tg-rg-T19229-Ab-1/ GM-Tg-rg-T19229-Ab-2Anti-Rat SLC46A1 monoclonal antibodyRat
GM-Tg-mg-T19229-Ab-1/ GM-Tg-mg-T19229-Ab-2Anti-Mouse SLC46A1 monoclonal antibodyMouse
GM-Tg-cynog-T19229-Ab-1/ GM-Tg-cynog-T19229-Ab-2Anti-Cynomolgus/ Rhesus macaque SLC46A1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T19229-Ab-1/ GM-Tg-felg-T19229-Ab-2Anti-Feline SLC46A1 monoclonal antibodyFeline
GM-Tg-cang-T19229-Ab-1/ GM-Tg-cang-T19229-Ab-2Anti-Canine SLC46A1 monoclonal antibodyCanine
GM-Tg-bovg-T19229-Ab-1/ GM-Tg-bovg-T19229-Ab-2Anti-Bovine SLC46A1 monoclonal antibodyBovine
GM-Tg-equg-T19229-Ab-1/ GM-Tg-equg-T19229-Ab-2Anti-Equine SLC46A1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T19229-Ab-1/ GM-Tg-hg-T19229-Ab-2; GM-Tg-rg-T19229-Ab-1/ GM-Tg-rg-T19229-Ab-2;
GM-Tg-mg-T19229-Ab-1/ GM-Tg-mg-T19229-Ab-2; GM-Tg-cynog-T19229-Ab-1/ GM-Tg-cynog-T19229-Ab-2;
GM-Tg-felg-T19229-Ab-1/ GM-Tg-felg-T19229-Ab-2; GM-Tg-cang-T19229-Ab-1/ GM-Tg-cang-T19229-Ab-2;
GM-Tg-bovg-T19229-Ab-1/ GM-Tg-bovg-T19229-Ab-2; GM-Tg-equg-T19229-Ab-1/ GM-Tg-equg-T19229-Ab-2
Products NameAnti-SLC46A1 monoclonal antibody
Formatmab
Target NameSLC46A1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SLC46A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PCFT/ SLC46A1/ G21 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm003784mouse Slc46a1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003784mouse Slc46a1 Lentivirus particle


    Target information

    Target IDGM-T19229
    Target NameSLC46A1
    Gene ID113235,52466,303333,708727,491166,101100096,511097,100072047
    Gene Symbol and Synonyms1110002C08Rik,D11Ertd18e,G21,HCP1,hPCFT,HsPCFT,PCFT,RGD1309472,rPCFT,SLC46A1,TRPE
    Uniprot AccessionQ96NT5,Q5EBA8,Q05B81
    Uniprot Entry NamePCFT_HUMAN,PCFT_RAT,PCFT_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000076351
    Target ClassificationN/A

    The target: SLC46A1, gene name: SLC46A1, also named as G21, HCP1, PCFT. This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.