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Anti-ONCM/ OSM functional antibody
Anti-ONCM/ OSM functional antibody for cell culture, ELISA & in-vivo assay
Go to OSM/OSM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T19556-Ab-1/ GM-Tg-hg-T19556-Ab-2 | Anti-Human OSM monoclonal antibody | Human |
| GM-Tg-rg-T19556-Ab-1/ GM-Tg-rg-T19556-Ab-2 | Anti-Rat OSM monoclonal antibody | Rat |
| GM-Tg-mg-T19556-Ab-1/ GM-Tg-mg-T19556-Ab-2 | Anti-Mouse OSM monoclonal antibody | Mouse |
| GM-Tg-cynog-T19556-Ab-1/ GM-Tg-cynog-T19556-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OSM monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T19556-Ab-1/ GM-Tg-felg-T19556-Ab-2 | Anti-Feline OSM monoclonal antibody | Feline |
| GM-Tg-cang-T19556-Ab-1/ GM-Tg-cang-T19556-Ab-2 | Anti-Canine OSM monoclonal antibody | Canine |
| GM-Tg-bovg-T19556-Ab-1/ GM-Tg-bovg-T19556-Ab-2 | Anti-Bovine OSM monoclonal antibody | Bovine |
| GM-Tg-equg-T19556-Ab-1/ GM-Tg-equg-T19556-Ab-2 | Anti-Equine OSM monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T19556-Ab-1/ GM-Tg-hg-T19556-Ab-2; GM-Tg-rg-T19556-Ab-1/ GM-Tg-rg-T19556-Ab-2; GM-Tg-mg-T19556-Ab-1/ GM-Tg-mg-T19556-Ab-2; GM-Tg-cynog-T19556-Ab-1/ GM-Tg-cynog-T19556-Ab-2; GM-Tg-felg-T19556-Ab-1/ GM-Tg-felg-T19556-Ab-2; GM-Tg-cang-T19556-Ab-1/ GM-Tg-cang-T19556-Ab-2; GM-Tg-bovg-T19556-Ab-1/ GM-Tg-bovg-T19556-Ab-2; GM-Tg-equg-T19556-Ab-1/ GM-Tg-equg-T19556-Ab-2 |
| Products Name | Anti-OSM monoclonal antibody |
| Format | mab |
| Target Name | OSM |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OSM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T19556-Ag-1 | Recombinant multi-species ONCM/ OSM protein |
| Cytokine | GM-Tg-g-T19556-Ag-1 | oncostatin M (OSM) protein |
| ORF Viral Vector | vGMAP000088 | Human OSM Adenovirus particle |
| ORF Viral Vector | vGMLP000497 | human OSM Lentivirus particle |
| ORF Viral Vector | pGMLP000497 | human OSM Lentivirus plasmid |
| ORF Viral Vector | pGMAP000088 | Human OSM Adenovirus plasmid |
| ORF Viral Vector | pGMLV000636 | house mouse osm Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001269 | mouse Osm Lentivirus plasmid |
| ORF Viral Vector | vGMLV000636 | house mouse osm Lentivirus particle |
| ORF Viral Vector | vGMLPm001269 | mouse Osm Lentivirus particle |
Target information
| Target ID | GM-T19556 |
| Target Name | OSM |
| Gene ID | 5008,18413,289747,717994,611921,101094379,319086,100064031 |
| Gene Symbol and Synonyms | OncoM,OSM |
| Uniprot Accession | P13725,Q65Z15,P53346 |
| Uniprot Entry Name | ONCM_HUMAN,ONCM_RAT,ONCM_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000099985 |
| Target Classification | N/A |
The target: OSM, gene name: OSM, also named as . This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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