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Anti-CCR8/ CC-CKR-8/ CCR-8 monoclonal antibody
Anti-CCR8/ CC-CKR-8/ CCR-8 antibody for FACS & in-vivo assay
Go to CCR8/CCR8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T20575-Ab-1/ GM-Tg-hg-T20575-Ab-2 | Anti-Human CCR8 monoclonal antibody | Human |
| GM-Tg-rg-T20575-Ab-1/ GM-Tg-rg-T20575-Ab-2 | Anti-Rat CCR8 monoclonal antibody | Rat |
| GM-Tg-mg-T20575-Ab-1/ GM-Tg-mg-T20575-Ab-2 | Anti-Mouse CCR8 monoclonal antibody | Mouse |
| GM-Tg-cynog-T20575-Ab-1/ GM-Tg-cynog-T20575-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCR8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T20575-Ab-1/ GM-Tg-felg-T20575-Ab-2 | Anti-Feline CCR8 monoclonal antibody | Feline |
| GM-Tg-cang-T20575-Ab-1/ GM-Tg-cang-T20575-Ab-2 | Anti-Canine CCR8 monoclonal antibody | Canine |
| GM-Tg-bovg-T20575-Ab-1/ GM-Tg-bovg-T20575-Ab-2 | Anti-Bovine CCR8 monoclonal antibody | Bovine |
| GM-Tg-equg-T20575-Ab-1/ GM-Tg-equg-T20575-Ab-2 | Anti-Equine CCR8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T20575-Ab-1/ GM-Tg-hg-T20575-Ab-2; GM-Tg-rg-T20575-Ab-1/ GM-Tg-rg-T20575-Ab-2; GM-Tg-mg-T20575-Ab-1/ GM-Tg-mg-T20575-Ab-2; GM-Tg-cynog-T20575-Ab-1/ GM-Tg-cynog-T20575-Ab-2; GM-Tg-felg-T20575-Ab-1/ GM-Tg-felg-T20575-Ab-2; GM-Tg-cang-T20575-Ab-1/ GM-Tg-cang-T20575-Ab-2; GM-Tg-bovg-T20575-Ab-1/ GM-Tg-bovg-T20575-Ab-2; GM-Tg-equg-T20575-Ab-1/ GM-Tg-equg-T20575-Ab-2 |
| Products Name | Anti-CCR8 monoclonal antibody |
| Format | mab |
| Target Name | CCR8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCR8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CCR8/ CC-CKR-8/ CCR-8 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T20575-Ag-1 | chemokine (C-C motif) receptor 8 (CCR8) protein |
| ORF Viral Vector | vGMLP003581 | human CCR8 Lentivirus particle |
| ORF Viral Vector | pGMLP003581 | human CCR8 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002781 | mouse Ccr8 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002781 | mouse Ccr8 Lentivirus particle |
Target information
| Target ID | GM-T20575 |
| Target Name | CCR8 |
| Gene ID | 1237,12776,301066,693806,485600,101099650,407772,100055409 |
| Gene Symbol and Synonyms | C-C,C-C CKR-8,CC-CKR-8,CCR-8,CCR8,CDw198,CKR-8,CKRL1,CMKBR8,CMKBRL2,CY6,GPRCY6,mCCR8,TER1 |
| Uniprot Accession | P51685,O97665 |
| Uniprot Entry Name | CCR8_HUMAN,CCR8_MACMU |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000179934 |
| Target Classification | GPCR |
The target: CCR8, gene name: CCR8, also named as CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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