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Anti-HIF-2A monoclonal antibody
Pre-made anti-HIF-2A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HIF-2A/EPAS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T21123-Ab-1/ GM-Tg-hg-T21123-Ab-2 | Anti-Human HIF-2A/EPAS1 monoclonal antibody | Human |
| GM-Tg-rg-T21123-Ab-1/ GM-Tg-rg-T21123-Ab-2 | Anti-Rat HIF-2A/EPAS1 monoclonal antibody | Rat |
| GM-Tg-mg-T21123-Ab-1/ GM-Tg-mg-T21123-Ab-2 | Anti-Mouse HIF-2A/EPAS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T21123-Ab-1/ GM-Tg-cynog-T21123-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HIF-2A/EPAS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T21123-Ab-1/ GM-Tg-felg-T21123-Ab-2 | Anti-Feline HIF-2A/EPAS1 monoclonal antibody | Feline |
| GM-Tg-cang-T21123-Ab-1/ GM-Tg-cang-T21123-Ab-2 | Anti-Canine HIF-2A/EPAS1 monoclonal antibody | Canine |
| GM-Tg-bovg-T21123-Ab-1/ GM-Tg-bovg-T21123-Ab-2 | Anti-Bovine HIF-2A/EPAS1 monoclonal antibody | Bovine |
| GM-Tg-equg-T21123-Ab-1/ GM-Tg-equg-T21123-Ab-2 | Anti-Equine HIF-2A/EPAS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T21123-Ab-1/ GM-Tg-hg-T21123-Ab-2; GM-Tg-rg-T21123-Ab-1/ GM-Tg-rg-T21123-Ab-2; GM-Tg-mg-T21123-Ab-1/ GM-Tg-mg-T21123-Ab-2; GM-Tg-cynog-T21123-Ab-1/ GM-Tg-cynog-T21123-Ab-2; GM-Tg-felg-T21123-Ab-1/ GM-Tg-felg-T21123-Ab-2; GM-Tg-cang-T21123-Ab-1/ GM-Tg-cang-T21123-Ab-2; GM-Tg-bovg-T21123-Ab-1/ GM-Tg-bovg-T21123-Ab-2; GM-Tg-equg-T21123-Ab-1/ GM-Tg-equg-T21123-Ab-2 |
| Products Name | Anti-HIF-2A/EPAS1 monoclonal antibody |
| Format | mab |
| Target Name | HIF-2A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HIF-2A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T21123-Ag-1 | Recombinant multi-species EPAS1/ HIF-2A/ ECYT4 protein |
| ORF Viral Vector | vGMAP000574 | Human EPAS1 Adenovirus particle |
| ORF Viral Vector | pGMAP000574 | Human EPAS1 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm004455 | mouse Epas1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004455 | mouse Epas1 Lentivirus particle |
Target information
| Target ID | GM-T21123 |
| Target Name | HIF-2A |
| Gene ID | 2034,13819,29452,714641,474578,101085621,282711,100068622 |
| Gene Symbol and Synonyms | bHLHe73,ECYT4,EPAS1,HIF-2 alpha,HIF-2alpha,HIF2 alpha,HIF2A,HLF,HRF,MOP2,PASD2 |
| Uniprot Accession | Q99814,Q9JHS1 |
| Uniprot Entry Name | EPAS1_HUMAN,EPAS1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000116016 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: HIF-2A, gene name: EPAS1, also named as ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73. This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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