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Anti-ITB6/ ITGB6/ AI1H monoclonal antibody
Anti-ITB6/ ITGB6/ AI1H antibody for FACS & in-vivo assay
Go to ITGB6/ITGB6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23178-Ab-1/ GM-Tg-hg-T23178-Ab-2 | Anti-Human ITGB6 monoclonal antibody | Human |
| GM-Tg-rg-T23178-Ab-1/ GM-Tg-rg-T23178-Ab-2 | Anti-Rat ITGB6 monoclonal antibody | Rat |
| GM-Tg-mg-T23178-Ab-1/ GM-Tg-mg-T23178-Ab-2 | Anti-Mouse ITGB6 monoclonal antibody | Mouse |
| GM-Tg-cynog-T23178-Ab-1/ GM-Tg-cynog-T23178-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ITGB6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23178-Ab-1/ GM-Tg-felg-T23178-Ab-2 | Anti-Feline ITGB6 monoclonal antibody | Feline |
| GM-Tg-cang-T23178-Ab-1/ GM-Tg-cang-T23178-Ab-2 | Anti-Canine ITGB6 monoclonal antibody | Canine |
| GM-Tg-bovg-T23178-Ab-1/ GM-Tg-bovg-T23178-Ab-2 | Anti-Bovine ITGB6 monoclonal antibody | Bovine |
| GM-Tg-equg-T23178-Ab-1/ GM-Tg-equg-T23178-Ab-2 | Anti-Equine ITGB6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23178-Ab-1/ GM-Tg-hg-T23178-Ab-2; GM-Tg-rg-T23178-Ab-1/ GM-Tg-rg-T23178-Ab-2; GM-Tg-mg-T23178-Ab-1/ GM-Tg-mg-T23178-Ab-2; GM-Tg-cynog-T23178-Ab-1/ GM-Tg-cynog-T23178-Ab-2; GM-Tg-felg-T23178-Ab-1/ GM-Tg-felg-T23178-Ab-2; GM-Tg-cang-T23178-Ab-1/ GM-Tg-cang-T23178-Ab-2; GM-Tg-bovg-T23178-Ab-1/ GM-Tg-bovg-T23178-Ab-2; GM-Tg-equg-T23178-Ab-1/ GM-Tg-equg-T23178-Ab-2 |
| Products Name | Anti-ITGB6 monoclonal antibody |
| Format | mab |
| Target Name | ITGB6 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ITGB6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ITB6/ ITGB6/ AI1H VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001331 | human ITGB6 Lentivirus particle |
| ORF Viral Vector | pGMLP001331 | human ITGB6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004088 | mouse Itgb6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004088 | mouse Itgb6 Lentivirus particle |
Target information
| Target ID | GM-T23178 |
| Target Name | ITGB6 |
| Gene ID | 3694,16420,311061,700454,488368,101094363,282644,100051266 |
| Gene Symbol and Synonyms | 2210409C20Rik,4831415H04Rik,AI1H,ITGB6 |
| Uniprot Accession | P18564,Q6AYF4,Q8SQB8 |
| Uniprot Entry Name | ITB6_HUMAN,ITB6_RAT,ITB6_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000115221 |
| Target Classification | N/A |
The target: ITGB6, gene name: ITGB6, also named as AI1H. This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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