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Anti-GALNS/ GALNAC6S/ GAS functional antibody
Anti-GALNS/ GALNAC6S/ GAS functional antibody for cell culture, ELISA & in-vivo assay
Go to GALNS/GALNS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23292-Ab-1/ GM-Tg-hg-T23292-Ab-2 | Anti-Human GALNS monoclonal antibody | Human |
| GM-Tg-rg-T23292-Ab-1/ GM-Tg-rg-T23292-Ab-2 | Anti-Rat GALNS monoclonal antibody | Rat |
| GM-Tg-mg-T23292-Ab-1/ GM-Tg-mg-T23292-Ab-2 | Anti-Mouse GALNS monoclonal antibody | Mouse |
| GM-Tg-cynog-T23292-Ab-1/ GM-Tg-cynog-T23292-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GALNS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23292-Ab-1/ GM-Tg-felg-T23292-Ab-2 | Anti-Feline GALNS monoclonal antibody | Feline |
| GM-Tg-cang-T23292-Ab-1/ GM-Tg-cang-T23292-Ab-2 | Anti-Canine GALNS monoclonal antibody | Canine |
| GM-Tg-bovg-T23292-Ab-1/ GM-Tg-bovg-T23292-Ab-2 | Anti-Bovine GALNS monoclonal antibody | Bovine |
| GM-Tg-equg-T23292-Ab-1/ GM-Tg-equg-T23292-Ab-2 | Anti-Equine GALNS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23292-Ab-1/ GM-Tg-hg-T23292-Ab-2; GM-Tg-rg-T23292-Ab-1/ GM-Tg-rg-T23292-Ab-2; GM-Tg-mg-T23292-Ab-1/ GM-Tg-mg-T23292-Ab-2; GM-Tg-cynog-T23292-Ab-1/ GM-Tg-cynog-T23292-Ab-2; GM-Tg-felg-T23292-Ab-1/ GM-Tg-felg-T23292-Ab-2; GM-Tg-cang-T23292-Ab-1/ GM-Tg-cang-T23292-Ab-2; GM-Tg-bovg-T23292-Ab-1/ GM-Tg-bovg-T23292-Ab-2; GM-Tg-equg-T23292-Ab-1/ GM-Tg-equg-T23292-Ab-2 |
| Products Name | Anti-GALNS monoclonal antibody |
| Format | mab |
| Target Name | GALNS |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GALNS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T23292-Ag-1 | Recombinant multi-species GALNS/ GALNAC6S/ GAS protein |
| ORF Viral Vector | vGMLP003327 | human GALNS Lentivirus particle |
| ORF Viral Vector | pGMLP003327 | human GALNS Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002754 | mouse Galns Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002754 | mouse Galns Lentivirus particle |
Target information
| Target ID | GM-T23292 |
| Target Name | GALNS |
| Gene ID | 2588,50917,292073,697850,489661,101099168,515809,100051284 |
| Gene Symbol and Synonyms | GalN6S,GALNAC6S,GALNS,GAS,mFLJ00319,MPS4A |
| Uniprot Accession | P34059,Q32KJ6,Q32KH5 |
| Uniprot Entry Name | GALNS_HUMAN,GALNS_RAT,GALNS_CANLF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000141012 |
| Target Classification | N/A |
The target: GALNS, gene name: GALNS, also named as GALNAC6S, GAS, GalN6S, MPS4A. This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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